Open Access

Neural stem cell transplantation for the treatment of primary torsion dystonia: A case report

  • Authors:
    • Wen‑Qing Ren
    • Feng Yin
    • Jian‑Ning Zhang
    • Wang‑Sheng Lu
    • Ying‑Kui Liang
    • Josefin Adlerberth
    • Zeng‑Min Tian
  • View Affiliations

  • Published online on: May 25, 2016     https://doi.org/10.3892/etm.2016.3392
  • Pages: 661-666
  • Copyright: © Ren et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Primary torsion dystonia (PTD) occurs due to a genetic mutation and often advances gradually. Currently, there is no therapy available that is able to inhibit progression. Neural stem cells (NSCs) are being investigated as potential therapies for neurodegenerative diseases, such as stroke and trauma. The present study evaluated the clinical effectiveness of NSC transplantation in an 18-year-old male patient with PTD, to assess the ability of this therapy to inhibit PTD progression. Genetic testing of the patient revealed a mutation in the torsion dystonia‑1 (DYT1) gene (907‑909 delGAG). NSCs were bilaterally implanted in the globus pallidus of the patient through stereotactic surgery. Prior to surgery, the patient's Burke-Fahn-Marsden dystonia movement score (BFMDMS) was 21, which progressively decreased after surgery to 18, 17, 15 and 13 at 1, 2, 3 and 4 postoperative years, respectively. BFMDMS was improved by 38.1% over the 4 postoperative years. Although computed tomography and magnetic resonance imaging examinations showed no significant changes prior to and following surgery, postoperative brain positron emission tomography scans revealed increased glucose metabolism in the transplanted region. The clinical efficacy of NSC transplantation in this patient suggests its potential for the treatment of DYT1‑positive patients with PTD.
View Figures
View References

Related Articles

Journal Cover

August-2016
Volume 12 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Ren WQ, Yin F, Zhang JN, Lu WS, Liang YK, Adlerberth J and Tian ZM: Neural stem cell transplantation for the treatment of primary torsion dystonia: A case report. Exp Ther Med 12: 661-666, 2016
APA
Ren, W., Yin, F., Zhang, J., Lu, W., Liang, Y., Adlerberth, J., & Tian, Z. (2016). Neural stem cell transplantation for the treatment of primary torsion dystonia: A case report. Experimental and Therapeutic Medicine, 12, 661-666. https://doi.org/10.3892/etm.2016.3392
MLA
Ren, W., Yin, F., Zhang, J., Lu, W., Liang, Y., Adlerberth, J., Tian, Z."Neural stem cell transplantation for the treatment of primary torsion dystonia: A case report". Experimental and Therapeutic Medicine 12.2 (2016): 661-666.
Chicago
Ren, W., Yin, F., Zhang, J., Lu, W., Liang, Y., Adlerberth, J., Tian, Z."Neural stem cell transplantation for the treatment of primary torsion dystonia: A case report". Experimental and Therapeutic Medicine 12, no. 2 (2016): 661-666. https://doi.org/10.3892/etm.2016.3392