Novel association of soluble intercellular adhesion molecule 1 and soluble P-selectin with the ABO blood group in a Chinese population

Zhang,Wenjing; Xu,Qun; Zhuang,Yunlong; Chen,Yuanfeng

doi:10.3892/etm.2016.3347

Novel association of soluble intercellular adhesion molecule 1 and soluble P-selectin with the ABO blood group in a Chinese population

Authors:
- Wenjing Zhang
- Qun Xu
- Yunlong Zhuang
- Yuanfeng Chen
View Affiliations

Affiliations: Blood Group Reference and Research Laboratory, Blood Center of Shandong, Jinan, Shandong 250012, P.R. China
Published online on: May 17, 2016 https://doi.org/10.3892/etm.2016.3347
Pages: 909-914
Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Recent studies have reported that the ABO gene can affect circulating expression levels of soluble intercellular adhesion molecule 1 (sICAM-1) and soluble P-selectin (sP-selectin) in Caucasians. However, several factors may affect the association, including the distribution and variations of the ABO gene, ethnic diversity and the inflammatory response status. The aim of the present study was to investigate this issue in Asian subjects of various blood groups. A total of 800 blood samples were randomly selected from healthy blood donors. The ABO blood groups were examined using standard serological tests, and ABO genotypes of group A and group AB specimens were analyzed. Plasma concentrations of sICAM‑1 and sP‑selectin were detected by standard enzyme‑linked immunosorbent assays. In healthy Chinese individuals, blood group A was detected to be significantly associated with lower circulating expression levels of sICAM‑1 and sP‑selectin, compared with group O. Individuals with ≥1 A1 allele had significantly lower expression levels of sICAM‑1 and sP‑selectin compared with all other ABO groups. The data indicate the significant association of ABO blood group antigens with sICAM‑1 and sP‑selectin expression levels in a healthy Chinese population, independent of the specific variations and distributions of ABO blood groups among ethnic populations. This result provides evidence for the previously unidentified role of ABO blood group antigens in the regulation of the inflammatory adhesion process. Accordingly, it can be proposed that ABO blood groups may require consideration when soluble adhesion molecules are identified as predictors for cardiovascular disease.

View Figures

View References

1	Dustin ML, Rothlein R, Bhan AK, Dinarello CA and Springer TA: Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J Immunol. 137:245–254. 1986.PubMed/NCBI
2	Pober JS, Gimbrone MA, Lapierre LA, Mendrick DL, Fiers W, Rothlein R and Springer TA: Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon. J Immunol. 137:1893–1896. 1986.PubMed/NCBI
3	Blankenberg S, Barbaux S and Tiret L: Adhesion molecules and atherosclerosis. Atherosclerosis. 170:191–203. 2003. View Article : Google Scholar : PubMed/NCBI
4	O'Malley T, Ludlam CA, Riemermsa RA and Fox KA: Early increase in levels of soluble inter-cellular adhesion molecule-1 (sICAM-1); potential risk factor for the acute coronary syndromes. Eur Heart J. 22:1226–1234. 2001. View Article : Google Scholar : PubMed/NCBI
5	Barbaux SC, Blankenberg S, Rupprecht HJ, Francomme C, Bickel C, Hafner G, Nicaud V, Meyer J, Cambien F and Tiret L: Association Between P-Selectin Gene Polymorphisms and Soluble P-Selectin Levels and Their Relation to Coronary Artery Disease. Arterioscler Thromb Vasc Biol. 21:1668–1673. 2001. View Article : Google Scholar : PubMed/NCBI
6	Lawson C and Wolf S: ICAM-1 signaling in endothelial cells. Pharmacol Rep. 61:22–32. 2009. View Article : Google Scholar : PubMed/NCBI
7	Van de Stolpe A and van der Saag PT: Intercellular adhesion molecule-1. J Mol Med (Berl). 74:13–33. 1996. View Article : Google Scholar : PubMed/NCBI
8	Rieckmann P, Michel U, Albrecht M, Brück W, Wöckel L and Felgenhauer K: Soluble forms of intercellular adhesion molecule-1 (ICAM-1) block lymphocyte attachment to cerebral endothelial cells. J Neuroimmunol. 60:9–15. 1995. View Article : Google Scholar : PubMed/NCBI
9	Hwang SJ, Ballantyne CM, Sharrett AR, Smith LC, Davis CE, Gotto AM and Boerwinkle E: Circulating adhesion molecules VCAM-1, ICAM-1 and E-selectin in carotid atherosclerosis and incident coronary heart disease cases: The Atherosclerosis Risk In Communities (ARIC) study. Circulation. 96:4219–4225. 1997. View Article : Google Scholar : PubMed/NCBI
10	O'malley T, Ludlam CA, Riemermsa RA and Fox KA: Early increase in levels of soluble inter-cellular adhesion molecule-1 (sICAM-1); potential risk factor for the acute coronary syndromes. Eur Heart J. 22:1226–1234. 2001. View Article : Google Scholar : PubMed/NCBI
11	Pradhan AD, Rifai N and Ridker PM: Soluble intercellular adhesion molecule-1, soluble vascular adhesion molecule-1 and the development of symptomatic peripheral arterial disease in men. Circulation. 106:820–825. 2002. View Article : Google Scholar : PubMed/NCBI
12	Albert MA, Glynn RJ, Buring JE and Ridker PM: Differential effect of soluble intercellular adhesion molecule-1 on the progression of atherosclerosis as compared to arterial thrombosis: A prospective analysis of the Women's Health Study. Atherosclerosis. 197:297–302. 2008. View Article : Google Scholar : PubMed/NCBI
13	Kansas GS: Selectins and their ligands: Current concepts and controversies. Blood. 88:3259–3287. 1996.PubMed/NCBI
14	Blann AD, Nadar SK and Lip GY: The adhesion molecule P-selectin and cardiovascular disease. Eur Heart J. 24:2166–2179. 2003. View Article : Google Scholar : PubMed/NCBI
15	Vianelli N, Catani L, Gugliotta L, Nocentini F, Baravelli S, Lancellotti G and Tura S: Increased P-selectin plasma levels in patients with thrombotic thrombocytopenic purpura. Haematologica. 81:3–7. 1996.PubMed/NCBI
16	Chong BH, Murray B, Bemdt MC, Dunlop LC, Brighton T and Chesterman CN: Plasma P-selectin is increased in thrombotic consumptive platelet disorders. Blood. 83:1535–1541. 1994.PubMed/NCBI
17	Katayama M, Handa M, Araki Y, Ambo H, Kawai Y, Watanabe K and Ikeda Y: Soluble P-selectin is present in normal circulation and its plasma level is elevated in patients with thrombotic thrombocytopenic purpura and haemolytic uraemic syndrome. Br J Haematol. 84:702–710. 1993. View Article : Google Scholar : PubMed/NCBI
18	Blann AD, Dobrotova M, Kubisz P and McCollum CN: Von Willebrand factor, soluble P-seletin, tissue plasminogen activator and plasminogen activator inhibitor in atherosclerosis. Thromb Haemost. 74:626–630. 1995.PubMed/NCBI
19	Carter AM, Anagnostopoulou K, Mansfield MW and Grant PJ: Soluble P-selectin levels, P-selectin polymorphisms and cardiovascular disease. J Thromb Haemost. 1:1718–1723. 2003. View Article : Google Scholar : PubMed/NCBI
20	Wu O, Bayoumi N, Vickers MA and Clark P: ABO (H) blood groups and vascular disease: A systematic review and meta-analysis. J Thromb Haemost. 6:62–69. 2008. View Article : Google Scholar : PubMed/NCBI
21	Paré G, Chasman DI, Kellogg M, Zee RY, Rifai N, Badola S, Miletich JP and Ridker PM: Novel association of ABO histo-blood group antigen with soluble ICAM-1: Results of a genome-wide association study of 6,578 women. PLoS Genet. 4:e10001182008. View Article : Google Scholar : PubMed/NCBI
22	Qi L, Cornelis MC, Kraft P, Jensen M, van Dam RM, Sun Q, Girman CJ, Laurie CC, Mirel DB, Hunter DJ, et al: Genetic variants in ABO blood group region, plasma soluble E-selectin levels and risk of type 2 diabetes. Hum Mol Genet. 19:1856–1862. 2010. View Article : Google Scholar : PubMed/NCBI
23	Yamamoto F and Hakomori S: Sugar-nucleotide donor specificity of histo-blood group A and B transferases is based on amino acid substitutions. J Biol Chem. 265:19257–19262. 1990.PubMed/NCBI
24	Tongmao Z: Human blood group genetics. Beijing: Science Press. 51–57. 1987.(In Chinese).
25	Reid ME and Lomas-Francis C: The Blood Group Antigen FactsbBook (Second Edition). ISBN: 978-0-12-586585-2.
26	Tongmao Z: Human blood group genetics. Beijing: Science Press. 32–35. 1987.(In Chinese).
27	Kobata A, Grollman EF and Ginsburg V: An enzymic basis for blood type A in humans. Arch Biochem Biophys. 124:609–612. 1968. View Article : Google Scholar : PubMed/NCBI
28	Race C, Ziderman D and Watkins WM: An K-D-galactosyltransferase associated with the blood group B character. Biochem J. 107:733–735. 1968. View Article : Google Scholar : PubMed/NCBI
29	Schachter H, Michaels MA, Crookston MC, Tilley CA and Crookston JH: A quantitative di¡erence in the activity of blood group A-specific N-acetylgalactosylaminyltransferase in serum from A1 and A2 human subjects. Biochem Biophys Res Commun. 45:1011–1018. 1971. View Article : Google Scholar : PubMed/NCBI
30	Daniels G: Human Blood Groups (Second). Blackwell Science Ltd.□. 2002.ISBN 0-632-056460. View Article : Google Scholar
31	Mollison PL, Engelfriet CP and Contreras M: Blood Transfusion in Medicine. Blackwell Science Oxford. 1997.
32	Barbalic M, Dupuis J, Dehghan A, Bis JC, Hoogeveen RC, Schnabel RB, Nambi V, Bretler M, Smith NL, Peters A, et al: Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels. Hum Mol Genet. 19:1863–1872. 2010. View Article : Google Scholar : PubMed/NCBI
33	Pathirana SL, Alles HK, Bandara S, Phone-Kyaw M, Perera MK, Wickremasinghe AR, Mendis KN and Handunnetti SM: ABO-blood-group types and protection against severe, Plasmodium falciparum malaria. Ann Trop Med Parasitol. 99:119–124. 2005. View Article : Google Scholar : PubMed/NCBI
34	Ben Q, Wang K, Yuan Y and Li Z: Pancreatic cancer incidence and outcome in relation to ABO blood groups among Han Chinese patients: A case-control study. Int J Cancer. 128:1179–1186. 2011. View Article : Google Scholar : PubMed/NCBI
35	Nakao M, Matsuo K, Hosono S, Ogata S, Ito H, Watanabe M, Mizuno N, Iida S, Sato S, Yatabe Y, et al: ABO blood group alleles and the risk of pancreatic cancer in a Japanese population. Cancer Sci. 102:1076–1080. 2011. View Article : Google Scholar : PubMed/NCBI
36	Teng MS, Hsu LA, Wu S, Chou HH, Chang CJ, Sun YZ, Juan SH and Ko YL: Mediation analysis reveals a sex-dependent association between ABO gene variants and TG/HDL-C ratio that is suppressed by sE-selectin level. Atherosclerossis. 228:406–412. 2013. View Article : Google Scholar
37	Otto VI, Damoc E, Cueni LN, Schürpf T, Frei R, Ali S, Callewaert N, Moise A, Leary JA, Folkers G and Przybylski M: N-glycan structures and N-glycosylation sites of mouse soluble intercellular adhesion molecule-1 revealed by MALDI-TOF and FTICR mass spectrometry. Glycobiology. 16:1033–1044. 2006. View Article : Google Scholar : PubMed/NCBI
38	Martinez M, Joffraud M, Giraud S, Baïsse B, Bernimoulin MP, Schapira M and Spertini O: Regulation of PSGL-1 interactions with L-selectin, P-selectin, and E-selectin: Role of human fucosyltransferase-IV and -VII. J Biol Chem. 280:5378–5390. 2005. View Article : Google Scholar : PubMed/NCBI