Open Access

Achievement of a target dose of bisoprolol may not be a preferred option for attenuating pressure overload‑induced cardiac hypertrophy and fibrosis

  • Authors:
    • Shizhao Xiang
    • Ning Zhang
    • Zheng Yang
    • Zhouyan Bian
    • Yuan Yuan
    • Qizhu Tang
  • View Affiliations

  • Published online on: August 4, 2016     https://doi.org/10.3892/etm.2016.3570
  • Pages: 2027-2038
  • Copyright: © Xiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Bisoprolol is a drug that acts via the mechanism of specifically and selectively inhibiting the β1‑adrenoreceptor in cardiac myocytes, and provides a pure reduction of heart rate without changing other cardiac parameters. It has long been clinically used to treat cerebrovascular and cardiovascular illnesses. However, there is little information available on whether the role of bisoprolol in the attenuation of ventricular remodeling is dependent upon the achievement of a target dose, and whether it must be used as a preferred option. The aim of the present study was to clarify the underlying benefits of bisoprolol in the attenuation of pressure overload‑induced cardiac hypertrophy and fibrosis at different doses. C57BL/6J male mice, aged 6‑8 weeks, were treated with saline or one of three different doses of bisoprolol (Biso: 2.5, 5 or 10 mg/kg/day) for 8 weeks from day 1 after aortic banding (AB). A number of mice underwent sham surgery and were treated with saline or bisoprolol. The mice were randomly assigned into the sham (n=24) and AB (n=62) groups. The results revealed that bisoprolol had a protective role against the cardiac hypertrophy, fibrosis and dysfunction caused by AB. This was determined on the basis of heart/body and lung/body weight ratios and heart weight/tibia length ratios, as well as echocardiographic and hemodynamic parameters, histological analysis, and the gene expression levels of hypertrophic and fibrotic markers. The present study revealed that administration of bisoprolol for a long time period may enhance its role in the prevention of cardiac hypertrophy and fibrosis induced by AB, whereas no statistically significant difference was observed between the middle‑ and high‑doses. These observations indicated that the function of bisoprolol in protecting against cardiac hypertrophy, fibrosis and dysfunction is time‑dependent. Furthermore, it is proposed that a middle dose of bisoprolol may be a better option for patients with cardiovascular illnesses, particularly those undertaking coronary artery bypass graft and cardiac pacemaker surgeries. These promising results require further clinical investigation.
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October-2016
Volume 12 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Xiang S, Zhang N, Yang Z, Bian Z, Yuan Y and Tang Q: Achievement of a target dose of bisoprolol may not be a preferred option for attenuating pressure overload‑induced cardiac hypertrophy and fibrosis. Exp Ther Med 12: 2027-2038, 2016
APA
Xiang, S., Zhang, N., Yang, Z., Bian, Z., Yuan, Y., & Tang, Q. (2016). Achievement of a target dose of bisoprolol may not be a preferred option for attenuating pressure overload‑induced cardiac hypertrophy and fibrosis. Experimental and Therapeutic Medicine, 12, 2027-2038. https://doi.org/10.3892/etm.2016.3570
MLA
Xiang, S., Zhang, N., Yang, Z., Bian, Z., Yuan, Y., Tang, Q."Achievement of a target dose of bisoprolol may not be a preferred option for attenuating pressure overload‑induced cardiac hypertrophy and fibrosis". Experimental and Therapeutic Medicine 12.4 (2016): 2027-2038.
Chicago
Xiang, S., Zhang, N., Yang, Z., Bian, Z., Yuan, Y., Tang, Q."Achievement of a target dose of bisoprolol may not be a preferred option for attenuating pressure overload‑induced cardiac hypertrophy and fibrosis". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2027-2038. https://doi.org/10.3892/etm.2016.3570