Debridement in chronic osteomyelitis with benign osteopetrosis: A case report
- Authors:
- Yu‑Ping Liu
- Xiang‑Hua Lin
- Man‑Yun Yan
- Bao‑Quan Lin
- Ming‑Ying Zhuo
View Affiliations
Affiliations: Department of Endocrinology and Metabolism, Xiamen Chang Gung Hospital, Xiamen, Fujian 361000, P.R. China, Department of Hematology, Xiamen Chang Gung Hospital, Xiamen, Fujian 361000, P.R. China, Department of Otorhinolaryngology, Xiamen Chang Gung Hospital, Xiamen, Fujian 361000, P.R. China
- Published online on: September 15, 2016 https://doi.org/10.3892/etm.2016.3706
-
Pages:
2811-2814
-
Copyright: © Liu
et al. This is an open access article distributed under the
terms of Creative
Commons Attribution License.
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Abstract
Osteopetrosis is a rare bone disease caused by metabolic imbalances as a result of genetic mutations. For instance, autosomal dominant osteopetrosis is caused by a missense mutation of the C1CN7 gene. This was first reported in 1904 and is thought to be caused by osteoclastic dysfunction and an impaired bone resorption ability. An accumulation of cortical bone mass during the remodeling of the medullary bone may increase the bone density and give rise to a hard marble consistency. Osteopetrosis can be divided into benign and malignant forms; however, no curative treatment exists for benign osteopetrosis. The management of complications, such as chronic osteomyelitis and fractures, serves a key role in influencing the patient survival rates. Previous studies have demonstrated that a combined treatment of hyperbaric oxygen (HBO) lavage for debridement of the necrotic region and high‑dose systemic antibiotics may be effective in the management of osteopetrosis. The present study reported a case of chronic mandible osteomyelitis and fistula occurring in association with maxillary sinusitis, who was successfully treated by through nasal endoscopy, using repeated flushing and cleaning every 2 weeks as a form of debridement, in the absence of high‑dose antibiotics and HBO.
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