Disease progression in Chinese patients with hepatitis C virus RNA‑positive infection via blood transfusion

  • Authors:
    • Yan‑Feng Pan
    • Yan Zheng
    • Tao Qin
    • Lei Feng
    • Qian Zhang
    • Xiao‑Gong Ping
    • Yan‑Ting Pan
    • Xiao‑Ping Wang
    • Li Bai
    • Hua‑Hua Li
  • View Affiliations

  • Published online on: October 11, 2016     https://doi.org/10.3892/etm.2016.3792
  • Pages: 3476-3484
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Abstract

The majority of patients with hepatitis C virus (HCV) in China were infected via blood transfusion prior to the year 1996. In this systematic retrospective cohort study, disease progression in 804 consecutive patients with transfusion‑acquired HCV is investigated. In addition, the occurrence of compensated cirrhosis, decompensated cirrhosis and hepatocellular carcinoma (HCC) is analyzed among these patients, along with the risk factors for disease progression. Patients with cirrhosis or HCC were classified as the serious development group (SD group) and the remaining patients with chronic hepatitis were classified as the hepatitis group (H group). Significant differences were found between the two groups in age at the time of infection, duration of infection and age at the time of observation. SD group patients were significantly older at the time of transfusion (33.73 vs. 23.56 years; P<0.001), with a significantly longer mean duration of HCV infection (21.88 vs. 21.15 years; P=0.029) compared with that in the H group. Male gender and age at the time of transfusion were significant risk factors for HCC (OR=2.48, P=0.031 and OR=1.07, P=0.002, respectively). Age was a significant risk factor for disease progression in older Chinese patients with transfusion‑acquired HCV, and there were significant differences in the prevalence of compensated cirrhosis, decompensated cirrhosis and HCC between the age groups (P<0.001), suggesting that more patients with HCV may develop cirrhosis or HCC in their third and fourth decades of infection. Results of the present study will be helpful for predicting disease progression in Chinese patients with HCV infected via blood transfusion.
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November-2016
Volume 12 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Pan YF, Zheng Y, Qin T, Feng L, Zhang Q, Ping XG, Pan YT, Wang XP, Bai L, Li HH, Li HH, et al: Disease progression in Chinese patients with hepatitis C virus RNA‑positive infection via blood transfusion. Exp Ther Med 12: 3476-3484, 2016
APA
Pan, Y., Zheng, Y., Qin, T., Feng, L., Zhang, Q., Ping, X. ... Li, H. (2016). Disease progression in Chinese patients with hepatitis C virus RNA‑positive infection via blood transfusion. Experimental and Therapeutic Medicine, 12, 3476-3484. https://doi.org/10.3892/etm.2016.3792
MLA
Pan, Y., Zheng, Y., Qin, T., Feng, L., Zhang, Q., Ping, X., Pan, Y., Wang, X., Bai, L., Li, H."Disease progression in Chinese patients with hepatitis C virus RNA‑positive infection via blood transfusion". Experimental and Therapeutic Medicine 12.5 (2016): 3476-3484.
Chicago
Pan, Y., Zheng, Y., Qin, T., Feng, L., Zhang, Q., Ping, X., Pan, Y., Wang, X., Bai, L., Li, H."Disease progression in Chinese patients with hepatitis C virus RNA‑positive infection via blood transfusion". Experimental and Therapeutic Medicine 12, no. 5 (2016): 3476-3484. https://doi.org/10.3892/etm.2016.3792