Acute fibrinous and organizing pneumonia: A case report and literature review

Xu,Xiao‑Yong; Chen,Fei; Chen,Chen; Sun,Hui‑Ming; Zhao,Bei‑Lei

doi:10.3892/etm.2016.3865

Acute fibrinous and organizing pneumonia: A case report and literature review

Authors:
- Xiao‑Yong Xu
- Fei Chen
- Chen Chen
- Hui‑Ming Sun
- Bei‑Lei Zhao
View Affiliations

Affiliations: Department of Pulmonary and Critical Care Medicine, Nanjing General Hospital of Nanjing Military Command, People's Liberation Army, Nanjing, Jiangsu 210002, P.R. China
Published online on: November 3, 2016 https://doi.org/10.3892/etm.2016.3865
Pages: 3958-3962
Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Acute fibrinous and organizing pneumonia (AFOP) is a rare lung disease with distinct histological characteristics that include the diffuse presence of intra‑alveolar fibrin, and the absence of eosinophils and hyaline membrane. In the present study, a case of AFOP that was diagnosed by lung biopsy is described. The patient presented with high fever and a cough with expectoration. Computed tomography of the lung showed the presence of bilateral patchy infiltrates, predominantly in the lower lobes. Histopathological examination of lung biopsy from the lower pulmonary lobe confirmed the pathological diagnosis. The patient showed a poor response to treatment with prednisone. Based on a review of literature pertaining to documented AFOP cases, a summary of the clinical features, radiological characteristics, treatment outcomes and prognoses associated with AFOP are presented. The most common pulmonary symptoms included cough, dyspnea and fever. The primary imaging findings in AFOP were consolidation and ground‑glass opacity in the bilateral lung.

View Figures

View References

1	Beasley MB, Franks TJ, Galvin JR, Gochuico B and Travis WD: Acute fibrinous and organizing pneumonia: A histological pattern of lung injury and possible variant of diffuse alveolar damage. Arch Pathol Lab Med. 126:1064–1070. 2002.PubMed/NCBI
2	Guimarães C, Sanches I and Ferreira C: Acute fibrinous and organising pneumonia. BMJ Case Rep. 2012:bcr01201136892012.PubMed/NCBI
3	Kobayashi H, Sugimoto C, Kanoh S, Motoyoshi K and Aida S: Acute fibrinous and organizing pneumonia: Initial presentation as a solitary nodule. J Thorac Imaging. 20:291–293. 2005. View Article : Google Scholar : PubMed/NCBI
4	Heo JY, Song JY, Noh JY, Yong HS, Cheong HJ and Kim WJ: Acute fibrinous and organizing pneumonia in a patient with HIV infection and Pneumocystis jiroveci pneumonia. Respirology. 15:1259–1261. 2010. View Article : Google Scholar : PubMed/NCBI
5	Damas C, Morais A, Moura CS and Marques A: Acute fibrinous and organizing pneumonia. Rev Port Pneumol. 12:615–620. 2006. View Article : Google Scholar : PubMed/NCBI
6	Valim V, Rocha RH, Couto RB, Paixão TS and Serrano EV: Acute fibrinous and organizing pneumonia and undifferentiated connective tissue disease: A case report. Case Rep Rheumatol. 2012:5492982012.PubMed/NCBI
7	Lee SM, Park JJ, Sung SH, Kim Y, Lee KE, Mun YC, Lee SN and Seong CM: Acute fibrinous and organizing pneumonia following hematopoietic stem cell transplantation. Korean J Intern Med. 24:156–159. 2009. View Article : Google Scholar : PubMed/NCBI
8	Hariri LP, Unizony S, Stone J, Mino-Kenudson M, Sharma A, Matsubara O and Mark EJ: Acute fibrinous and organizing pneumonia in systemic lupus erythematosus: A case report and review of the literature. Pathol Int. 60:755–759. 2010. View Article : Google Scholar : PubMed/NCBI
9	Otto C, Huzly D, Kemna L, Hüttel A, Benk C, Rieg S, Ploenes T, Werner M and Kayser G: Acute fibrinous and organizing pneumonia associated with influenza A/H1N1 pneumonia after lung transplantation. BMC Pulm Med. 13:302013. View Article : Google Scholar : PubMed/NCBI
10	Feng AN, Cai HR, Zhou Q, Zhang YF and Meng FQ: Diagnostic problems related to acute fibrinous and organizing pneumonia: Misdiagnosis in 2 cases of lung consolidation and occupying lesions. Int J Clin Exp Pathol. 7:4493–4497. 2014.PubMed/NCBI
11	Labarinas S, Gumy-Pause F, Rougemont AL, Baerlocher G, Leibundgut EO, Porret N, Schäppi MG, Barazzone-Argiroffo C, Passweg J, Merlini L, et al: Is acute fibrinous and organizing pneumonia the expression of immune dysregulation? J Pediatr Hematol Oncol. 35:139–143. 2013. View Article : Google Scholar : PubMed/NCBI
12	Rapaka V, Hussain MA, Niazi M and Diaz-Fuentes G: Severe acute fibrinous and organizing pneumonia causing acute respiratory distress syndrome and shock. J Bronchology Interv Pulmonol. 18:269–273. 2011. View Article : Google Scholar : PubMed/NCBI
13	Bhatti S, Hakeem A, Torrealba J, McMahon JP and Meyer KC: Severe acute fibrinous and organizing pneumonia (AFOP) causing ventilatory failure: Successful treatment with mycophenolate mofetil and corticosteroids. Respir Med. 103:1764–1767. 2009. View Article : Google Scholar : PubMed/NCBI
14	Renaud-Picard B, Dégot T, Biondini D, Weingertner N, Reeb J, Chenard MP and Kessler R: Successful lung retransplantation in a patient with acute fibrinous and organizing pneumonia: A case report. Transplant Proc. 47:182–185. 2015. View Article : Google Scholar : PubMed/NCBI
15	Xu Y, Ding Hz, Hu T and Qh W: Acute fibrinous and organizing pneumonia: A case report and review of the literature. Lin Chuang Fei Ke Za Zhi. 1:186–189. 2014.(in Chinese).
16	Miao LY, Dai JH, Gui XH, Zhang DP and FQ M: The clinical pathological features of acute fibrinous and organizing pneumonia. Lin Chuang Fei Ke Za Zhi. 9:1260–1262. 2010.(in Chinese).
17	Gui XH, Zhang YW, Dai JH, Cai HR, Xiao YL, Meng FQ and Chen B: Acute Fibrinous and Organizing Pneumonia: Two case reports and literature review. Chinese Journal of Respiratory and Critical Care Medicine. 6:558–561. 2012.
18	Zhang J, Fang QH, Feng RE, Ma YM, Cao Y and Wang RG: Acute fibrinous and organizing pneumonia: A case report and review of the literature. Zhonghua Jie He He Hu Xi Za Zhi. 33:892–895. 2010.(In Chinese). PubMed/NCBI
19	Qiu YY, Miao LY, Cai HR, Xiao YL, Ye Q, Meng FQ and Feng AN: The clinicopathological features of acute fibrinous and organizing pneumonia. Zhonghua Jie He He Hu Xi Za Zhi. 36:425–430. 2013.(In Chinese). PubMed/NCBI
20	Garcia BA, Goede T and Mohammed TL: Acute fibrinous organizing pneumonia: A case report and literature review. Curr Probl Diagn Radiol. 44:469–471. 2015. View Article : Google Scholar : PubMed/NCBI
21	Piciucchi S, Dubini A, Tomassetti S, Casoni G, Ravaglia C and Poletti V: A case of amiodarone-induced acute fibrinous and organizing pneumonia mimicking mesothelioma. Am J Respir Crit Care Med. 191:104–106. 2015. View Article : Google Scholar : PubMed/NCBI
22	Sauter JL and Butnor KJ: Expanding the spectrum of pulmonary histopathological manifestations of anti-synthetase syndrome: Anti-EJ-associated acute fibrinous and organizing pneumonia. Histopathology. 65:581–582. 2014. View Article : Google Scholar : PubMed/NCBI
23	Prahalad S, Bohnsack JF, Maloney CG and Leslie KO: Fatal acute fibrinous and organizing pneumonia in a child with juvenile dermatomyositis. J Pediatr. 146:289–292. 2005. View Article : Google Scholar : PubMed/NCBI
24	Vasu TS, Cavallazzi R, Hirani A and Marik PE: A 64-year-old male with fever and persistent lung infiltrate. Respir Care. 54:1263–1265. 2009.PubMed/NCBI
25	Yokogawa N and Alcid DV: Acute fibrinous and organizing pneumonia as a rare presentation of abacavir hypersensitivity reaction. AIDS. 21:2116–2117. 2007. View Article : Google Scholar : PubMed/NCBI
26	Travis WD, Costabel U, Hansell DM, King TE Jr, Lynch DA, Nicholson AG, Ryerson CJ, Ryu JH, Selman M, Wells AU, et al: ATS/ERS Committee on Idiopathic Interstitial Pneumonias: An official American thoracic society/European respiratory society statement: Update of the international multidisciplinary classification of the idiopathic interstitial pneumonias. Am J Respir Crit Care Med. 188:733–748. 2013. View Article : Google Scholar : PubMed/NCBI