Open Access

Diagnostic value of neutrophil gelatinase-associated lipocalin for renal injury in asphyxiated preterm infants

  • Authors:
    • Yu'e Song
    • Shuzhen Sun
    • Yonghui Yu
    • Gang Li
    • Jia Song
    • Hong Zhang
    • Chunmei Yan
  • View Affiliations

  • Published online on: February 7, 2017     https://doi.org/10.3892/etm.2017.4107
  • Pages: 1245-1248
  • Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The aim of the present study was to analyze the diagnostic value of neutrophil gelatinase-associated lipocalin (NGAL) in renal injury in asphyxiated preterm infants. In total, 48 cases of asphyxiated preterm infants, 45 cases of premature infants and 45 cases of normal newborn infants were included in the study. Using ELISA we evaluated the level of urine NGAL, kidney injury molecule-1 (KIM‑1), cystatin C (Cys-C) and serum creatinine (Scr). We also calculated the estimated glomerular filtration rate (eGFR). Our results showed that NGAL, KIM-1 and Cys-C levels in the group of asphyxiant renal injury within 24 and 48 h were markedly higher than the other two groups (P<0.05), while changes in Scr and eGFR within 24 h were not significant (P>0.05). Scr level in renal injury group within 48 h was markedly elevated while the eGFR level was visibly reduced (P<0.05). According to analysis of receiver operating characteristic curve, area under curve for NGAL in the group of asphyxiant renal injury within 24 and 48 h was significantly higher than KIM-1 and Cys-C. Susceptibility and specificity were improved. In conclusion, diagnosis of renal injury in asphyxia neonates using NGAL was more efficient compared to other methods.
View Figures
View References

Related Articles

Journal Cover

April-2017
Volume 13 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Song Y, Sun S, Yu Y, Li G, Song J, Zhang H and Yan C: Diagnostic value of neutrophil gelatinase-associated lipocalin for renal injury in asphyxiated preterm infants. Exp Ther Med 13: 1245-1248, 2017
APA
Song, Y., Sun, S., Yu, Y., Li, G., Song, J., Zhang, H., & Yan, C. (2017). Diagnostic value of neutrophil gelatinase-associated lipocalin for renal injury in asphyxiated preterm infants. Experimental and Therapeutic Medicine, 13, 1245-1248. https://doi.org/10.3892/etm.2017.4107
MLA
Song, Y., Sun, S., Yu, Y., Li, G., Song, J., Zhang, H., Yan, C."Diagnostic value of neutrophil gelatinase-associated lipocalin for renal injury in asphyxiated preterm infants". Experimental and Therapeutic Medicine 13.4 (2017): 1245-1248.
Chicago
Song, Y., Sun, S., Yu, Y., Li, G., Song, J., Zhang, H., Yan, C."Diagnostic value of neutrophil gelatinase-associated lipocalin for renal injury in asphyxiated preterm infants". Experimental and Therapeutic Medicine 13, no. 4 (2017): 1245-1248. https://doi.org/10.3892/etm.2017.4107