Protective effects of baicalin on rabbit articular chondrocytes in vitro Corrigendum in /10.3892/etm.2021.9768 Retraction in /10.3892/etm.2023.12236

Huang,Xianyuan; Wu,Huayu; Wang,Liqin; Zheng,Li; Zhao,Jinmin

doi:10.3892/etm.2017.4116

Protective effects of baicalin on rabbit articular chondrocytes in vitro Corrigendum in /10.3892/etm.2021.9768

Retraction in: /10.3892/etm.2023.12236

Protective effects of baicalin on rabbit articular chondrocytes in vitro

Corrigendum in: /10.3892/etm.2021.9768 Retraction in /10.3892/etm.2023.12236

Authors:
- Xianyuan Huang
- Huayu Wu
- Liqin Wang
- Li Zheng
- Jinmin Zhao
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Affiliations: Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Department of Cell Biology and Genetics, School of Premedical Sciences, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Department of Radiology, The First Affiliated Hospital, Sun Yat‑Sen University, Guangzhou, Guangdong 510275, P.R. China
Published online on: February 10, 2017 https://doi.org/10.3892/etm.2017.4116
Pages: 1267-1274
Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Drug therapy is one of the typical treatments for post‑injury inflammation of cartilage. Traditional Chinese herbs have potential as treatments, as their long history of clinical application has demonstrated they are effective and induce minimal side effects. Baicalin is a traditional Chinese medicine that has been used to treat inflammation, fever, ulcers and cancer for hundreds of years. Previous studies have demonstrated that baicalin may decrease levels of interleukin‑1β and suppress the expression of type‑I collagen, thus attenuating cartilage degeneration. In the present study, the effect of baicalin on chondrocytes was assessed by examining the morphology, proliferation, extracellular matrix (ECM) synthesis and cartilage‑specific gene expression of chondrocytes. The results indicated that baicalin may promote the proliferation of articular chondrocytes, secretion of cartilage ECM and collagen type II, aggrecan and SRY box (Sox) 9 gene upregulation. The expression of collagen I, a marker of chondrocyte dedifferentiation, was downregulated by baicalin; therefore, baicalin may maintain the phenotype of chondrocytes. Within the recommended concentrations of baicalin ranging from 0.625‑6.25 µmol/l cell proliferation was increased and a 1.25 µmol/l dose of baicalin exerted the most positive effect on articular chondrocytes. The results of the present study may therefore indicate that baicalin may be used as a novel agent promoting the repair of articular cartilage damage.

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