Salvianolic acid B attenuates lipopolysaccharide‑induced acute lung injury in rats through inhibition of apoptosis, oxidative stress and inflammation

  • Authors:
    • Da‑Hai Zhao
    • Yu‑Jie Wu
    • Shu‑Ting Liu
    • Rong‑Yu Liu
  • View Affiliations

  • Published online on: June 1, 2017     https://doi.org/10.3892/etm.2017.4534
  • Pages: 759-764
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The present study was performed to assess the protective effect of salvianolic acid B on lipopolysaccharide (LPS)‑induced acute lung injury (ALI). Sprague Dawley rats were injected with 100 µg/kg LPS through a 24‑gauge catheter. One group of rats was pre‑treated with salvianolic acid B (1 mg/ml; 20 ml/kg body weight) 1 h prior to LPS challenge, then 20 ml/kg salvianolic acid B every 2 days for 4 weeks thereafter. Salvianolic acid B attenuated LPS‑induced increases in the lung wet/dry weight rate and lung tissue injury in ALI model rats. LPS‑induced changes in the content of caspase‑3, malondialdehyde, superoxide dismutase, catalase, glutathione peroxidase, tumor necrosis factor‑α and interleukin‑6 in ALI model rats were attenuated by treatment with salvianolic acid B. Furthermore, treatment with salvianolic acid B inhibited the protein expression of type I collagen I, endogenous transforming growth factor‑β1 production and α‑smooth muscle actin in ALI model rats. These findings indicated that salvianolic acid B attenuates LPS‑induced ALI through inhibition of apoptosis, oxidative stress and inflammation in rats and therefore exertsa protective effect against ALI.
View Figures
View References

Related Articles

Journal Cover

July-2017
Volume 14 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zhao DH, Wu YJ, Liu ST and Liu RY: Salvianolic acid B attenuates lipopolysaccharide‑induced acute lung injury in rats through inhibition of apoptosis, oxidative stress and inflammation. Exp Ther Med 14: 759-764, 2017
APA
Zhao, D., Wu, Y., Liu, S., & Liu, R. (2017). Salvianolic acid B attenuates lipopolysaccharide‑induced acute lung injury in rats through inhibition of apoptosis, oxidative stress and inflammation. Experimental and Therapeutic Medicine, 14, 759-764. https://doi.org/10.3892/etm.2017.4534
MLA
Zhao, D., Wu, Y., Liu, S., Liu, R."Salvianolic acid B attenuates lipopolysaccharide‑induced acute lung injury in rats through inhibition of apoptosis, oxidative stress and inflammation". Experimental and Therapeutic Medicine 14.1 (2017): 759-764.
Chicago
Zhao, D., Wu, Y., Liu, S., Liu, R."Salvianolic acid B attenuates lipopolysaccharide‑induced acute lung injury in rats through inhibition of apoptosis, oxidative stress and inflammation". Experimental and Therapeutic Medicine 14, no. 1 (2017): 759-764. https://doi.org/10.3892/etm.2017.4534