Open Access

Alteration of Th17 and Foxp3+ regulatory T cells in patients with unexplained recurrent spontaneous abortion before and after the therapy of hCG combined with immunoglobulin

  • Authors:
    • Jing Sha
    • Fumin Liu
    • Jingfang Zhai
    • Xiaoyun Liu
    • Qinglin Zhang
    • Bei Zhang
  • View Affiliations

  • Published online on: June 9, 2017     https://doi.org/10.3892/etm.2017.4574
  • Pages: 1114-1118
  • Copyright: © Sha et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

We conducted this study to investigate the effects of the combination therapy of human chorionic gonadotropin (hCG) plus immunoglobulin (IG) on the levels of T helper 17 (Th17) cells and Foxp3+ regulatory T cells (Treg) in patients with unexplained recurrent spontaneous abortion (URSA). Twenty pregnant women with URSA underwent combination therapy of hCG plus IG. Flow cytometry was performed to measure the proportions of Th17 and Treg cells before and after treatment. RT-PCR and ELISA were applied to detect the concentrations of interleukin (IL)-17, IL-6, IL-10, and transforming growth factor (TGF)-β1 in the peripheral blood. The therapy of hCG combined with IG may induce a decrease in the Th17/Treg ratio and the Treg bias, which may be beneficial for the maintenance of pregnancy. The levels of Th17 cells and related cytokines IL-17 and IL-6 decreased after the treatment (P<0.05). At the same time, levels of Treg cells and the related cytokines IL-10 and TGF-β1 increased (P<0.05). The Th17/Treg ratio decreased significantly after treatment. In conclusion, the occurrence of URSA may be associated with the Th17/Treg balance disorder, and correcting the disorder may be one of the mechanisms behind the efficacy of combination therapy for URSA.
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August-2017
Volume 14 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Sha J, Liu F, Zhai J, Liu X, Zhang Q and Zhang B: Alteration of Th17 and Foxp3+ regulatory T cells in patients with unexplained recurrent spontaneous abortion before and after the therapy of hCG combined with immunoglobulin. Exp Ther Med 14: 1114-1118, 2017
APA
Sha, J., Liu, F., Zhai, J., Liu, X., Zhang, Q., & Zhang, B. (2017). Alteration of Th17 and Foxp3+ regulatory T cells in patients with unexplained recurrent spontaneous abortion before and after the therapy of hCG combined with immunoglobulin. Experimental and Therapeutic Medicine, 14, 1114-1118. https://doi.org/10.3892/etm.2017.4574
MLA
Sha, J., Liu, F., Zhai, J., Liu, X., Zhang, Q., Zhang, B."Alteration of Th17 and Foxp3+ regulatory T cells in patients with unexplained recurrent spontaneous abortion before and after the therapy of hCG combined with immunoglobulin". Experimental and Therapeutic Medicine 14.2 (2017): 1114-1118.
Chicago
Sha, J., Liu, F., Zhai, J., Liu, X., Zhang, Q., Zhang, B."Alteration of Th17 and Foxp3+ regulatory T cells in patients with unexplained recurrent spontaneous abortion before and after the therapy of hCG combined with immunoglobulin". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1114-1118. https://doi.org/10.3892/etm.2017.4574