Curcumin protects against acute renal injury by suppressing JAK2/STAT3 pathway in severe acute pancreatitis in rats

  • Authors:
    • Shuaijun Zhu
    • Chi Zhang
    • Qinyong Weng
    • Bing Ye
  • View Affiliations

  • Published online on: June 22, 2017     https://doi.org/10.3892/etm.2017.4647
  • Pages: 1669-1674
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Abstract

The aim of the present study was to investigate the effect of curcumin on acute renal injury in a rat model of severe acute pancreatitis (SAP). A SAP model with acute kidney injury was established in rats by retrograde injection of 5% sodium taurocholate into the pancreatic duct. The serum amylase, creatinine (Cr) and blood urea nitrogen (BUN) levels in rats were measured. Hematoxylin and eosin staining was used to assess pancreatic and renal histological changes. Serum tumor necrosis factor (TNF)‑α and interleukin (IL)‑6 levels were measured using ELISA kits. Renal protein levels of Janus kinase (JAK) 2/signal transducer and activator of transcription (STAT) 3 pathway components were determined by western blot assay. The results showed that curcumin significantly decreased serum amylase, Cr and BUN levels, and alleviated pancreatic and renal histological changes in SAP rats. Furthermore, curcumin markedly decreased serum TNF‑α and IL‑6 levels and downregulated renal protein levels of JAK2/STAT3 pathway components. These results proved that curcumin ameliorates acute renal injury in a rat model of SAP. The molecular mechanism of its effect may be associated with the suppression of the JAK2/STAT3 pathway to reduce TNF‑α and IL‑6 levels in SAP‑induced acute renal injury. Therefore, the findings of the present study revealed the potential use of curcumin for the prevention and treatment of SAP and the associated renal injury.

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August 2017
Volume 14 Issue 2

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APA
Zhu, S., Zhang, C., Weng, Q., & Ye, B. (2017). Curcumin protects against acute renal injury by suppressing JAK2/STAT3 pathway in severe acute pancreatitis in rats. Experimental and Therapeutic Medicine, 14, 1669-1674. https://doi.org/10.3892/etm.2017.4647
MLA
Zhu, S., Zhang, C., Weng, Q., Ye, B."Curcumin protects against acute renal injury by suppressing JAK2/STAT3 pathway in severe acute pancreatitis in rats". Experimental and Therapeutic Medicine 14.2 (2017): 1669-1674.
Chicago
Zhu, S., Zhang, C., Weng, Q., Ye, B."Curcumin protects against acute renal injury by suppressing JAK2/STAT3 pathway in severe acute pancreatitis in rats". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1669-1674. https://doi.org/10.3892/etm.2017.4647