Polycomb group proteins: Novel molecules associated with ultraviolet A‑induced photoaging of human skin

Wu,Zhuoxia; Zhang,Lianbo

doi:10.3892/etm.2017.4807

September-2017 Volume 14 Issue 3

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September-2017 Volume 14 Issue 3

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Article Open Access

Polycomb group proteins: Novel molecules associated with ultraviolet A‑induced photoaging of human skin

Authors:
- Zhuoxia Wu
- Lianbo Zhang
View Affiliations / Copyright

Affiliations: Department of Plastic and Reconstructive Surgery, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China

Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 2554-2562
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Published online on: July 19, 2017

https://doi.org/10.3892/etm.2017.4807
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Abstract

Epigenetic repressor polycomb group (PcG) proteins are thought to serve a role in a number of cellular processes, including carcinogenesis, senescence, apoptosis and DNA repair. In the present study, long‑wave ultraviolet A (UVA) was used to irradiate human skin fibroblasts (HSFs) and embryonic skin fibroblasts (ESFs) in order to simulate photoaging of the skin. The results of cell proliferation, apoptosis, hyaluronic acid (HA) content and reverse transcription-quantitative polymerase chain reaction assays revealed that the expression levels of genes encoding key PcG proteins (BMI‑1 and EZH2) were altered. In addition, the expression levels of these genes were associated with the expression of enzymes that regulate HA synthesis. Furthermore, the expression levels of PcG proteins differed between HSFs and ESFs, suggesting that PcG proteins serve a role in altering HA synthesis during the UVA‑induced fibroblast aging process. This signaling pathway may represent a novel molecular mechanism regulating the photoaging of the skin. The findings of the present study provide important insights into the underlying mechanisms of photoaging of the human skin. Further studies are required to clarify the molecular mechanisms underling skin aging and to identify targets for the clinical treatment of photoaging.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Polycomb group proteins: Novel molecules associated with ultraviolet A‑induced photoaging of human skin

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