Open Access

Desmopressin plus anticholinergic agent in the treatment of nocturnal enuresis: A meta-analysis

  • Authors:
    • Jianyong Yu
    • Zhaojun Yan
    • Shiying Zhou
    • Feng Han
    • Feng Xiao
    • Jian Han
    • Congling Sun
  • View Affiliations

  • Published online on: August 7, 2017     https://doi.org/10.3892/etm.2017.4897
  • Pages: 2875-2884
  • Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The present study aimed to evaluate the clinical efficacy and safety of combination therapy comprising desmopressin plus anticholinergic agent compared with desmopressin alone for children with nocturnal enuresis (NE). A meta‑analysis of 8 eligible studies was performed to analyze the effects of desmopressin plus anticholinergic agent combination therapy and desmopressin monotherapy in the treatment of NE in children. The overall odds ratio (OR) or standardized mean difference (SMD) and 95% confidence interval were calculated for full responders (FR), partial responders (PR), non‑responders (NR), the change in the mean number of wet nights and adverse events. Following 1 month of treatment, efficacy analysis yielded an OR of 3.736, which suggested that the proportion of FR for patients treated with the combination therapy was higher than that for patients treated with monotherapy. Analysis of the change in the mean number of wet nights yielded an SMD of 0.719, which indicated that the change in the mean number of wet nights in the patients treated with combination therapy was greater than that in the patients treated with monotherapy. Following 3 months of treatment, the OR calculated for FR plus PR compared with NR was 2.857, indicating that the proportion of FR and PR was elevated by the combination therapy compared with desmopressin alone. The OR for adverse events was 4.074, which suggested that the combination therapy did not lead to more adverse events in the treatment of NE. Therefore, the present meta‑analysis suggests that, compared with desmopressin monotherapy, a combination therapy comprising desmopressin and anticholinergic agent is more effective with equivalent safety for children with NE.

Related Articles

Journal Cover

October-2017
Volume 14 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Yu J, Yan Z, Zhou S, Han F, Xiao F, Han J and Sun C: Desmopressin plus anticholinergic agent in the treatment of nocturnal enuresis: A meta-analysis. Exp Ther Med 14: 2875-2884, 2017
APA
Yu, J., Yan, Z., Zhou, S., Han, F., Xiao, F., Han, J., & Sun, C. (2017). Desmopressin plus anticholinergic agent in the treatment of nocturnal enuresis: A meta-analysis. Experimental and Therapeutic Medicine, 14, 2875-2884. https://doi.org/10.3892/etm.2017.4897
MLA
Yu, J., Yan, Z., Zhou, S., Han, F., Xiao, F., Han, J., Sun, C."Desmopressin plus anticholinergic agent in the treatment of nocturnal enuresis: A meta-analysis". Experimental and Therapeutic Medicine 14.4 (2017): 2875-2884.
Chicago
Yu, J., Yan, Z., Zhou, S., Han, F., Xiao, F., Han, J., Sun, C."Desmopressin plus anticholinergic agent in the treatment of nocturnal enuresis: A meta-analysis". Experimental and Therapeutic Medicine 14, no. 4 (2017): 2875-2884. https://doi.org/10.3892/etm.2017.4897