Elevation of PTPN1 promoter methylation is a significant risk factor of type 2 diabetes in the Chinese population
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- Published online on: August 11, 2017 https://doi.org/10.3892/etm.2017.4924
- Pages: 2976-2982
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Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
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Abstract
The present study aimed to investigate the contribution of DNA methylation of the protein tyrosine phosphatase, non‑receptor type 1 (PTPN1) gene to the susceptibility to type 2 diabetes (T2D). Peripheral blood mononuclear cells (PBMCs) were collected from 97 patients with T2D and 97 age‑ and gender‑matched controls. DNA methylation of the PTPN1 gene promoter was evaluated by bisulfite pyrosequencing. Independent sample t‑tests were used to compare the differences in the PTPN1 promoter and other phenotypes between the patients with T2D and the controls. The results indicated a significant correlation between PTPN1 promoter methylation and the risk of T2D. Additionally, a breakdown analysis by gender revealed that PTPN1 methylation was associated with an increased risk of T2D in females. Furthermore, low‑density lipoprotein (r=‑0.183, P=0.046) and total cholesterol (r=‑0.310, P=0.001) were inversely associated with PTPN1 methylation in females. In conclusion, the results indicate that elevated PTPN1 promoter methylation is a risk factor for T2D in the female Chinese population.
