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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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October-2017 Volume 14 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

A crossover study of the combination therapy of metformin and exenatide or biphasic insulin aspart 30 in overweight or obese patients newly diagnosed with type 2 diabetes mellitus

  • Authors:
    • Huibiao Quan
    • Huachuan Zhang
    • Weiping Wei
    • Tuanyu Fang
    • Daoxiong Chen
    • Kaining Chen

  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, People's Hospital of Hainan, Haikou, Hainan 570311, P.R. China
  • Pages: 3279-3287
    |
    Published online on: August 2, 2017
       https://doi.org/10.3892/etm.2017.4863
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Abstract

The aim of the present study was to explore the effects of various combinations of exenatide, metformin (MET) and biphasic insulin aspart 30 (BIA30) on type 2 diabetes mellitus (T2DM). Two hundred overweight or obese patients newly diagnosed with T2DM were evenly randomized into two groups: A (twice daily for all: Phase I, 5 µg exenatide + 0.5 g MET for 4 weeks, then 10 µg exenatide + 0.5 g MET for 8 weeks; Phase II, 0.5 g MET for 12 weeks; Phase III, 0.3‑0.4 U/kg/day BIA30 + 0.5 g MET for 12 weeks) and B (Phases I, II, III matched the phases III, II and I in group A). In groups A and B a significant decrease and increase, respectively, in glycated hemoglobin (HbAlc) and body mass index (BMI) was noted during Phase I. A 3.2±0.4‑kg decrease in body weight in group A and a 2.6±0.3‑kg increase in group B was observed. In Phase II, HbAlc was significantly increased in both groups (P<0.05). In Phase III, the BMI was increased in group A and reduced in group B (P<0.05). There was a 3.8±0.4‑kg weight decrease in group B and 4.2±0.5‑kg increase in group A (P<0.05). The combination of exenatide and MET promoted weight loss, glycemic control, β‑cell function index, C peptide and adiponectin levels. These results suggested that the combination of exenatide and MET is better than the combination of BIA and MET for the therapy of overweight or obese patients newly diagnosed with T2DM.

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Copy and paste a formatted citation
Spandidos Publications style
Quan H, Zhang H, Wei W, Fang T, Chen D and Chen K: A crossover study of the combination therapy of metformin and exenatide or biphasic insulin aspart 30 in overweight or obese patients newly diagnosed with type 2 diabetes mellitus. Exp Ther Med 14: 3279-3287, 2017.
APA
Quan, H., Zhang, H., Wei, W., Fang, T., Chen, D., & Chen, K. (2017). A crossover study of the combination therapy of metformin and exenatide or biphasic insulin aspart 30 in overweight or obese patients newly diagnosed with type 2 diabetes mellitus. Experimental and Therapeutic Medicine, 14, 3279-3287. https://doi.org/10.3892/etm.2017.4863
MLA
Quan, H., Zhang, H., Wei, W., Fang, T., Chen, D., Chen, K."A crossover study of the combination therapy of metformin and exenatide or biphasic insulin aspart 30 in overweight or obese patients newly diagnosed with type 2 diabetes mellitus". Experimental and Therapeutic Medicine 14.4 (2017): 3279-3287.
Chicago
Quan, H., Zhang, H., Wei, W., Fang, T., Chen, D., Chen, K."A crossover study of the combination therapy of metformin and exenatide or biphasic insulin aspart 30 in overweight or obese patients newly diagnosed with type 2 diabetes mellitus". Experimental and Therapeutic Medicine 14, no. 4 (2017): 3279-3287. https://doi.org/10.3892/etm.2017.4863
Copy and paste a formatted citation
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Spandidos Publications style
Quan H, Zhang H, Wei W, Fang T, Chen D and Chen K: A crossover study of the combination therapy of metformin and exenatide or biphasic insulin aspart 30 in overweight or obese patients newly diagnosed with type 2 diabetes mellitus. Exp Ther Med 14: 3279-3287, 2017.
APA
Quan, H., Zhang, H., Wei, W., Fang, T., Chen, D., & Chen, K. (2017). A crossover study of the combination therapy of metformin and exenatide or biphasic insulin aspart 30 in overweight or obese patients newly diagnosed with type 2 diabetes mellitus. Experimental and Therapeutic Medicine, 14, 3279-3287. https://doi.org/10.3892/etm.2017.4863
MLA
Quan, H., Zhang, H., Wei, W., Fang, T., Chen, D., Chen, K."A crossover study of the combination therapy of metformin and exenatide or biphasic insulin aspart 30 in overweight or obese patients newly diagnosed with type 2 diabetes mellitus". Experimental and Therapeutic Medicine 14.4 (2017): 3279-3287.
Chicago
Quan, H., Zhang, H., Wei, W., Fang, T., Chen, D., Chen, K."A crossover study of the combination therapy of metformin and exenatide or biphasic insulin aspart 30 in overweight or obese patients newly diagnosed with type 2 diabetes mellitus". Experimental and Therapeutic Medicine 14, no. 4 (2017): 3279-3287. https://doi.org/10.3892/etm.2017.4863
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