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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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Article Open Access

Human umbilical cord mesenchymal stem cells increase interleukin-9 production of CD4+ T cells

  • Authors:
    • Zhou Xin Yang
    • Ying Chi
    • Yue Ru Ji
    • You Wei Wang
    • Jing Zhang
    • Wei Feng Luo
    • Li Na Li
    • Cai Dong Hu
    • Guang Sheng Zhuo
    • Li Fang Wang
    • Zhi‑Bo Han
    • Zhong Chao Han

  • View Affiliations / Copyright

    Affiliations: The State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences and Peking Union of Medical College, Tianjin 300020, P.R. China, Zhejiang Provincial Key Laboratory of Geriatrics, Zhejiang Hospital, Hangzhou, Zhejiang 310013, P.R. China, School of Medicine, Jinan University, Guangzhou, Guangdong 510632, P.R. China, Beijing Institute of Health and Stem Cells, Beijing 100176, P.R. China, Department of Basic Medicine, Zhejiang Medical College, Hangzhou, Zhejiang 310053, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3541-3548
    |
    Published online on: August 17, 2017
       https://doi.org/10.3892/etm.2017.4952
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Abstract

Mesenchymal stem cells (MSC) are able to differentiate into cells of multiple lineage, and additionally act to modulate the immune response. Interleukin (IL)‑9 is primarily produced by cluster of differentiation (CD)4+ T cells to regulate the immune response. The present study aimed to investigate the effect of human umbilical cord derived‑MSC (UC‑MSC) on IL‑9 production of human CD4+ T cells. It was demonstrated that the addition of UC‑MSC to the culture of CD4+ T cells significantly enhanced IL‑9 production by CD4+ T cells. Transwell experiments suggested that UC‑MSC promotion of IL‑9 production by CD4+ T cells was dependent on cell‑cell contact. Upregulated expression of CD106 was observed in UC‑MSC co‑cultured with CD4+ T cells, and the addition of a blocking antibody of CD106 significantly impaired the ability of UC‑MSC to promote IL‑9 production by CD4+ T cells. Therefore, the results of the present study demonstrated that UC‑MSC promoted the generation of IL‑9 producing cells, which may be mediated, in part by CD106. The findings may act to expand understanding and knowledge of the immune modulatory role of UC‑MSC.

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Copy and paste a formatted citation
Spandidos Publications style
Yang ZX, Chi Y, Ji YR, Wang YW, Zhang J, Luo WF, Li LN, Hu CD, Zhuo GS, Wang LF, Wang LF, et al: Human umbilical cord mesenchymal stem cells increase interleukin-9 production of CD4+ T cells. Exp Ther Med 14: 3541-3548, 2017.
APA
Yang, Z.X., Chi, Y., Ji, Y.R., Wang, Y.W., Zhang, J., Luo, W.F. ... Han, Z.C. (2017). Human umbilical cord mesenchymal stem cells increase interleukin-9 production of CD4+ T cells. Experimental and Therapeutic Medicine, 14, 3541-3548. https://doi.org/10.3892/etm.2017.4952
MLA
Yang, Z. X., Chi, Y., Ji, Y. R., Wang, Y. W., Zhang, J., Luo, W. F., Li, L. N., Hu, C. D., Zhuo, G. S., Wang, L. F., Han, Z., Han, Z. C."Human umbilical cord mesenchymal stem cells increase interleukin-9 production of CD4+ T cells". Experimental and Therapeutic Medicine 14.4 (2017): 3541-3548.
Chicago
Yang, Z. X., Chi, Y., Ji, Y. R., Wang, Y. W., Zhang, J., Luo, W. F., Li, L. N., Hu, C. D., Zhuo, G. S., Wang, L. F., Han, Z., Han, Z. C."Human umbilical cord mesenchymal stem cells increase interleukin-9 production of CD4+ T cells". Experimental and Therapeutic Medicine 14, no. 4 (2017): 3541-3548. https://doi.org/10.3892/etm.2017.4952
Copy and paste a formatted citation
x
Spandidos Publications style
Yang ZX, Chi Y, Ji YR, Wang YW, Zhang J, Luo WF, Li LN, Hu CD, Zhuo GS, Wang LF, Wang LF, et al: Human umbilical cord mesenchymal stem cells increase interleukin-9 production of CD4+ T cells. Exp Ther Med 14: 3541-3548, 2017.
APA
Yang, Z.X., Chi, Y., Ji, Y.R., Wang, Y.W., Zhang, J., Luo, W.F. ... Han, Z.C. (2017). Human umbilical cord mesenchymal stem cells increase interleukin-9 production of CD4+ T cells. Experimental and Therapeutic Medicine, 14, 3541-3548. https://doi.org/10.3892/etm.2017.4952
MLA
Yang, Z. X., Chi, Y., Ji, Y. R., Wang, Y. W., Zhang, J., Luo, W. F., Li, L. N., Hu, C. D., Zhuo, G. S., Wang, L. F., Han, Z., Han, Z. C."Human umbilical cord mesenchymal stem cells increase interleukin-9 production of CD4+ T cells". Experimental and Therapeutic Medicine 14.4 (2017): 3541-3548.
Chicago
Yang, Z. X., Chi, Y., Ji, Y. R., Wang, Y. W., Zhang, J., Luo, W. F., Li, L. N., Hu, C. D., Zhuo, G. S., Wang, L. F., Han, Z., Han, Z. C."Human umbilical cord mesenchymal stem cells increase interleukin-9 production of CD4+ T cells". Experimental and Therapeutic Medicine 14, no. 4 (2017): 3541-3548. https://doi.org/10.3892/etm.2017.4952
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