Thalidomide and its analogues: A review of the potential for immunomodulation of fibrosis diseases and opthalmopathy (Review)

  • Authors:
    • Ting Liu
    • Feng Guo
    • Xiaomin Zhu
    • Xiangge He
    • Lin Xie
  • View Affiliations

  • Published online on: September 27, 2017     https://doi.org/10.3892/etm.2017.5209
  • Pages:5251-5257
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Abstract

The US Food and Drug Administration approved thalidomide and its analogues for the treatment of erythema nodosum leprosum, in spite of the notoriety of reports of severe birth defects in the middle of the last century. As immunomodulatory drugs, thalidomide and its analogues have been used to effectively treat various diseases. In the present review, preclinical data about the effects of thalidomide and its analogues on the immune system are integrated, including the effects of cytokines on transdifferentiation, the anti‑inflammatory effect, immune cell function regulation and angiogenesis. The present review also investigates the latest developments of thalidomide as a therapeutic option for the treatment of idiopathic pulmonary fibrosis, skin fibrosis, and ophthalmopathies.

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December 2017
Volume 14 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
(total number of cites)

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APA
Liu, T., Guo, F., Zhu, X., He, X., & Xie, L. (2017). Thalidomide and its analogues: A review of the potential for immunomodulation of fibrosis diseases and opthalmopathy (Review). Experimental and Therapeutic Medicine, 14, 5251-5257. https://doi.org/10.3892/etm.2017.5209
MLA
Liu, T., Guo, F., Zhu, X., He, X., Xie, L."Thalidomide and its analogues: A review of the potential for immunomodulation of fibrosis diseases and opthalmopathy (Review)". Experimental and Therapeutic Medicine 14.6 (2017): 5251-5257.
Chicago
Liu, T., Guo, F., Zhu, X., He, X., Xie, L."Thalidomide and its analogues: A review of the potential for immunomodulation of fibrosis diseases and opthalmopathy (Review)". Experimental and Therapeutic Medicine 14, no. 6 (2017): 5251-5257. https://doi.org/10.3892/etm.2017.5209