Open Access

Niu‑Huang‑Shen suppresses hepatocellular carcinoma cell growth and metastasis by regulating Yap1 expression

  • Authors:
    • Yanfang Peng
    • Yingqian Zhao
    • Taisheng Ye
    • Yabing Zhang
    • Zhaoyan Wu
    • Yukun Xia
    • Yingwen Zhang
  • View Affiliations

  • Published online on: October 2, 2017     https://doi.org/10.3892/etm.2017.5247
  • Pages:5459-5463
  • Copyright: © Peng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hepatocellular carcinoma (HCC) is one of the most common cancers types. Niu‑Huang‑Shen (NHS), a Chinese medicine, has been reported to exert antipyretic, anti‑inflammatory and vasodilatation effects. However, whether NHS has inhibitory effects on HCC cell phenotypes has remained elusive. In the present study, Cell Counting Kit‑8, colony formation, fluorescence-activated cell sorting and Transwell assays were used to evaluate the effect of NHS on cell proliferation, migration and invasion. The results indicated that NHS suppressed cell proliferation and invasion, inhibited cell apoptosis, and induced cell cycle arrest. In addition, NHS significantly suppressed the mRNA and protein expression of Yes‑associated protein (YAP). It was concluded that NHS downregulated YAP expression and inhibited the Hippo signaling pathway as well as HCC cell growth and invasion. NHS may be a novel potential therapeutic for HCC patients.

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December 2017
Volume 14 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
Peng, Y., Zhao, Y., Ye, T., Zhang, Y., Wu, Z., Xia, Y., & Zhang, Y. (2017). Niu‑Huang‑Shen suppresses hepatocellular carcinoma cell growth and metastasis by regulating Yap1 expression. Experimental and Therapeutic Medicine, 14, 5459-5463. https://doi.org/10.3892/etm.2017.5247
MLA
Peng, Y., Zhao, Y., Ye, T., Zhang, Y., Wu, Z., Xia, Y., Zhang, Y."Niu‑Huang‑Shen suppresses hepatocellular carcinoma cell growth and metastasis by regulating Yap1 expression". Experimental and Therapeutic Medicine 14.6 (2017): 5459-5463.
Chicago
Peng, Y., Zhao, Y., Ye, T., Zhang, Y., Wu, Z., Xia, Y., Zhang, Y."Niu‑Huang‑Shen suppresses hepatocellular carcinoma cell growth and metastasis by regulating Yap1 expression". Experimental and Therapeutic Medicine 14, no. 6 (2017): 5459-5463. https://doi.org/10.3892/etm.2017.5247