Vascular corrosion casting of normal and pre‑eclamptic placentas

  • Authors:
    • Geping Yin
    • Ming Chen
    • Juan Li
    • Xiaoli Zhao
    • Shujun Yang
    • Xiuyun Li
    • Zheng Yuan
    • Aifang Wu
  • View Affiliations

  • Published online on: September 27, 2017     https://doi.org/10.3892/etm.2017.5207
  • Pages:5535-5539
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Abstract

Pre‑eclampsia is an important cause of maternal and fetal morbidity and mortality that is associated with decreased placental perfusion. In the present study, vascular corrosion casting was used to investigate the differences in structural changes of the fetoplacental vasculature between normal and pre‑eclamptic placentas. An improved epoxy resin vascular casting technique was used in the present study. Casting media were infused into 40 normal and 40 pre‑eclamptic placentas through umbilical arteries and veins in order to construct three dimensional fetoplacental vasculatures. The number of branches, diameter, morphology and peripheral artery‑to‑vein ratio were measured for each specimen. The results indicated that the venous system of normal placentas was divided into 5‑7 grades of branches and the volume of the vascular bed was 155.5±45.3 ml. In severe pre‑eclamptic placentas, the volume was 106.4±36.1 ml, which was significantly lower compared with normal placentas (P<0.01). The venous system of pre‑eclamptic placentas was divided into 4‑5 grades of branches, which was much more sparse compared with normal placentas. In additions, the diameters of grade 1‑3 veins and grade 2‑3 arteries were significantly smaller in severe pre‑eclampsia (P<0.05). In conclusion, pre‑eclamptic placentas displayed a decreased volume of vascular bed, smaller diameters of grade 1‑3 veins and grade 2‑3 arteries, and an increased peripheral artery‑to‑vein ratio, which may be a cause of the placental dysfunction during severe pre‑eclampsia.

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December 2017
Volume 14 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
Yin, G., Chen, M., Li, J., Zhao, X., Yang, S., Li, X. ... Wu, A. (2017). Vascular corrosion casting of normal and pre‑eclamptic placentas. Experimental and Therapeutic Medicine, 14, 5535-5539. https://doi.org/10.3892/etm.2017.5207
MLA
Yin, G., Chen, M., Li, J., Zhao, X., Yang, S., Li, X., Yuan, Z., Wu, A."Vascular corrosion casting of normal and pre‑eclamptic placentas". Experimental and Therapeutic Medicine 14.6 (2017): 5535-5539.
Chicago
Yin, G., Chen, M., Li, J., Zhao, X., Yang, S., Li, X., Yuan, Z., Wu, A."Vascular corrosion casting of normal and pre‑eclamptic placentas". Experimental and Therapeutic Medicine 14, no. 6 (2017): 5535-5539. https://doi.org/10.3892/etm.2017.5207