miR‑34a and miR‑125b are upregulated in peripheral blood mononuclear cells from patients with type 2 diabetes mellitus

  • Authors:
    • Yanxin Shen
    • Huiling Xu
    • Xiaoyuan Pan
    • Weijiang Wu
    • Hui Wang
    • Linlin Yan
    • Miaomiao Zhang
    • Xia Liu
    • Sheng Xia
    • Qixiang Shao
  • View Affiliations

  • Published online on: October 3, 2017     https://doi.org/10.3892/etm.2017.5254
  • Pages:5589-5596
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Abstract

Type 2 diabetes mellitus (T2DM) is a leading cause of blindness, non‑traumatic amputation and end‑stage renal disease, as well as a major cardiovascular risk factor. To determine whether miR‑125b and miR‑34a serve an important role in the development of T2DM, the current study investigated the expression profile of two microRNAs (miR‑34a and miR‑125b) and their relative genes in peripheral blood mononuclear cells from 73 patients with T2DM and 52 healthy donors by reverse transcription‑quantitative polymerase chain reaction In addition, the association between miR‑34a, miR‑125b and their relevant genes expression profile were analyzed with respect to the pathogenesis of T2DM. The present study demonstrated that the expression levels of miR‑125b and miR‑34a were elevated in peripheral blood mononuclear cell samples from patients with T2DM. Furthermore, miR‑34a and miR‑125b were positively correlated with low‑density lipoprotein/high‑density lipoprotein (HDL) and Foxp3 and negatively related to triglyceride/HDL. However, no correlation among miR‑34a, miR‑125b and the value of homeostasis model assessment of insulin resistance, homeostasis model assessment of β‑cell function and the genes of B lymphocyte‑induced maturation protein‑1, interferon regulatory factor‑4, P53 and retinoid‑related orphan receptor γt were observed. These results indicate that the alteration of miR‑34a and miR‑125b exists in patients with T2DM, which may be involved in the pathogenesis of T2DM, and could be a potential novel biomarker of T2DM.

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December 2017
Volume 14 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
Shen, Y., Xu, H., Pan, X., Wu, W., Wang, H., Yan, L. ... Shao, Q. (2017). miR‑34a and miR‑125b are upregulated in peripheral blood mononuclear cells from patients with type 2 diabetes mellitus. Experimental and Therapeutic Medicine, 14, 5589-5596. https://doi.org/10.3892/etm.2017.5254
MLA
Shen, Y., Xu, H., Pan, X., Wu, W., Wang, H., Yan, L., Zhang, M., Liu, X., Xia, S., Shao, Q."miR‑34a and miR‑125b are upregulated in peripheral blood mononuclear cells from patients with type 2 diabetes mellitus". Experimental and Therapeutic Medicine 14.6 (2017): 5589-5596.
Chicago
Shen, Y., Xu, H., Pan, X., Wu, W., Wang, H., Yan, L., Zhang, M., Liu, X., Xia, S., Shao, Q."miR‑34a and miR‑125b are upregulated in peripheral blood mononuclear cells from patients with type 2 diabetes mellitus". Experimental and Therapeutic Medicine 14, no. 6 (2017): 5589-5596. https://doi.org/10.3892/etm.2017.5254