Open Access

Effects of Bambusa tulda on the proliferation of human stem cells

  • Authors:
    • Hyunjin Lee
    • Mohammad Salah Uddin
    • Sang Woo Lee
    • Sangho Choi
    • Jun‑Beom Park
  • View Affiliations

  • Published online on: October 10, 2017     https://doi.org/10.3892/etm.2017.5276
  • Pages:5696-5702
  • Copyright: © Lee et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

To date, the effects of Bambusa tulda on stem cells have not been thoroughly assessed. The present study aimed to evaluate the effects of Bambusa tulda extract on the morphology and proliferative potential of human mesenchymal stem cells derived from the gingiva. The stem cells were cultured in a growth medium in the presence of Bambusa tulda methanolic extract (BBT) at concentrations ranging from 0.001 to 1%. Evaluation of cell morphology and cellular proliferation as well as immunofluorescent assays for collagen I were performed on days 1, 3, 5 and 7. Stem cells in the control group displayed a fibroblast‑like morphology, and BBT treatment did not produce any noticeable morphological changes. However, application of 1% BBT produced a significant increase in cell proliferation. BBT, particularly at the concentration of 1%, also caused a noticeable increase of collagen I expression at day 1 and day 3. Based on these findings, it was concluded that BBT exerted beneficial effects on the proliferation of mesenchymal stem cells and enhanced collagen I expression at early time points.

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Journal Cover

December 2017
Volume 14 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
Lee, H., Uddin, M.S., Lee, S.W., Choi, S., & Park, J. (2017). Effects of Bambusa tulda on the proliferation of human stem cells. Experimental and Therapeutic Medicine, 14, 5696-5702. https://doi.org/10.3892/etm.2017.5276
MLA
Lee, H., Uddin, M. S., Lee, S. W., Choi, S., Park, J."Effects of Bambusa tulda on the proliferation of human stem cells". Experimental and Therapeutic Medicine 14.6 (2017): 5696-5702.
Chicago
Lee, H., Uddin, M. S., Lee, S. W., Choi, S., Park, J."Effects of Bambusa tulda on the proliferation of human stem cells". Experimental and Therapeutic Medicine 14, no. 6 (2017): 5696-5702. https://doi.org/10.3892/etm.2017.5276