Open Access

Protective efficacy of inhaled quercetin for radiation pneumonitis

  • Authors:
    • Meng Qin
    • Weijuan Chen
    • Juanjuan Cui
    • Wentao Li
    • Dongmei Liu
    • Weifen Zhang
  • View Affiliations

  • Published online on: October 11, 2017     https://doi.org/10.3892/etm.2017.5290
  • Pages:5773-5778
  • Copyright: © Qin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Radiation pneumonitis is a clinical problem with a high incidence. Once the onset of radiation pneumonitis has occurred, the administration of antioxidants and anti‑inflammatory agents is the most commonly used method of clinical treatment. Quercetin (Que) is a common flavonoid, with potent anti‑inflammatory and anti‑oxidant activities. In the present study, the therapeutic effect of inhaled Que on radiation‑induced radiation pneumonitis in rats was investigated. Treatment with Que via inhalation was shown to increase the number of leukocytes and erythrocytes in the blood, and reduce the number of inflammatory cells in bronchoalveolar lavage fluid. Histological examination of lung tissue indicated that inhaled Que reduced hemorrhaging and the infiltration of inflammatory cells, and suppressed the expression of the proinflammatory cytokines transforming growth factor‑β1 and interleukin‑6. These results indicated that treatment with Que via inhalation ameliorates radiation pneumonitis by reducing the number of inflammatory cells, and attenuating the inflammatory response and pathological changes. This suggests that administration of Que via inhalation has the potential to become a novel treatment for radiation pneumonitis.

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December 2017
Volume 14 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
Qin, M., Chen, W., Cui, J., Li, W., Liu, D., & Zhang, W. (2017). Protective efficacy of inhaled quercetin for radiation pneumonitis. Experimental and Therapeutic Medicine, 14, 5773-5778. https://doi.org/10.3892/etm.2017.5290
MLA
Qin, M., Chen, W., Cui, J., Li, W., Liu, D., Zhang, W."Protective efficacy of inhaled quercetin for radiation pneumonitis". Experimental and Therapeutic Medicine 14.6 (2017): 5773-5778.
Chicago
Qin, M., Chen, W., Cui, J., Li, W., Liu, D., Zhang, W."Protective efficacy of inhaled quercetin for radiation pneumonitis". Experimental and Therapeutic Medicine 14, no. 6 (2017): 5773-5778. https://doi.org/10.3892/etm.2017.5290