Open Access

Amelioration of the DSS‑induced colitis in mice by pretreatment with 4,4'‑diaponeurosporene‑producing Bacillus subtilis

  • Authors:
    • Yuchao Jing
    • Haofei Liu
    • Wenwen Xu
    • Qian Yang
  • View Affiliations

  • Published online on: October 11, 2017     https://doi.org/10.3892/etm.2017.5282
  • Pages:6069-6073
  • Copyright: © Jing et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Inflammatory bowel disease (IBD) is a chronically relapsing inflammatory disorder of the gastrointestinal tract. Current IBD treatments have poor tolerability and insufficient therapeutic efficacy, thus, alternative therapeutic approaches are required. Recently, a number of dietary supplements have emerged as promising interventions. In the present study oral administration of a carotenoid (4,4'‑diaponeurosporene)‑producing Bacillus subtilis markedly ameliorated dextran sulfate sodium salt‑induced mouse colitis, as demonstrated by a reduction in weight loss and the severity of bleeding, which indicated that 4,4'‑diaponeurosporene may have beneficial effects on treatments for colitis. This preliminary study indicated that 4,4'‑diaponeurosporene may function synergistically with probiotics to provide a novel and effective strategy to prevent colitis.

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December 2017
Volume 14 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
Jing, Y., Liu, H., Xu, W., & Yang, Q. (2017). Amelioration of the DSS‑induced colitis in mice by pretreatment with 4,4'‑diaponeurosporene‑producing Bacillus subtilis. Experimental and Therapeutic Medicine, 14, 6069-6073. https://doi.org/10.3892/etm.2017.5282
MLA
Jing, Y., Liu, H., Xu, W., Yang, Q."Amelioration of the DSS‑induced colitis in mice by pretreatment with 4,4'‑diaponeurosporene‑producing Bacillus subtilis". Experimental and Therapeutic Medicine 14.6 (2017): 6069-6073.
Chicago
Jing, Y., Liu, H., Xu, W., Yang, Q."Amelioration of the DSS‑induced colitis in mice by pretreatment with 4,4'‑diaponeurosporene‑producing Bacillus subtilis". Experimental and Therapeutic Medicine 14, no. 6 (2017): 6069-6073. https://doi.org/10.3892/etm.2017.5282