Magnesium isoglycyrrhizinate ameliorates doxorubicin‑induced acute cardiac and hepatic toxicity via anti‑oxidant and anti‑apoptotic mechanisms in mice

  • Authors:
    • Zhonglin Wu
    • Yuanyuan Zhang
    • Tao Song
    • Qiongtao Song
    • Ying Zhang
    • Xuan Zhang
    • Xue Han
    • Jianping Zhang
    • Li Chu
  • View Affiliations

  • Published online on: November 8, 2017     https://doi.org/10.3892/etm.2017.5470
  • Pages:1005-1012
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Abstract

The present study investigated the effects and potential mechanisms of action of magnesium isoglycyrrhizinate (MgIG) in doxorubicin (DOX)‑treated mice. Histopathological analysis and western blot analysis were conducted in the liver and heart tissues and biochemical analysis of the serum was performed. The results revealed that MgIG (10, 20 and 40 mg/kg/day) could protect the structure and functions of the liver and heart by inhibiting the activities of the myocardial enzymes creatine kinase (CK), CK‑MB and lactate dehydrogenase and the hepatic‑specific enzymes aspirate aminotransferase and alanine aminotransferase, increasing the activities of the antioxidants superoxide dismutase and glutathione peroxidase, and inhibiting cellular apoptosis induced by DOX (30 mg/kg). These results demonstrate that inhibiting lipid peroxidation and reducing myocardial and hepatocyte apoptosis may be one of the mechanisms by which MgIG exhibits hepatoprotective and cardioprotective effects in DOX‑treated mice.

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January 2018
Volume 15 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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APA
Wu, Z., Zhang, Y., Song, T., Song, Q., Zhang, Y., Zhang, X. ... Chu, L. (2018). Magnesium isoglycyrrhizinate ameliorates doxorubicin‑induced acute cardiac and hepatic toxicity via anti‑oxidant and anti‑apoptotic mechanisms in mice. Experimental and Therapeutic Medicine, 15, 1005-1012. https://doi.org/10.3892/etm.2017.5470
MLA
Wu, Z., Zhang, Y., Song, T., Song, Q., Zhang, Y., Zhang, X., Han, X., Zhang, J., Chu, L."Magnesium isoglycyrrhizinate ameliorates doxorubicin‑induced acute cardiac and hepatic toxicity via anti‑oxidant and anti‑apoptotic mechanisms in mice". Experimental and Therapeutic Medicine 15.1 (2018): 1005-1012.
Chicago
Wu, Z., Zhang, Y., Song, T., Song, Q., Zhang, Y., Zhang, X., Han, X., Zhang, J., Chu, L."Magnesium isoglycyrrhizinate ameliorates doxorubicin‑induced acute cardiac and hepatic toxicity via anti‑oxidant and anti‑apoptotic mechanisms in mice". Experimental and Therapeutic Medicine 15, no. 1 (2018): 1005-1012. https://doi.org/10.3892/etm.2017.5470