Neuroprotective effect of berberine against learning and memory deficits in diffuse axonal injury

  • Authors:
    • Hong‑Cai Wang
    • Bo‑Ding Wang
    • Mao‑Song Chen
    • Hai Chen
    • Cheng‑Feng Sun
    • Gang Shen
    • Jian‑Min Zhang
  • View Affiliations

  • Published online on: November 13, 2017     https://doi.org/10.3892/etm.2017.5496
  • Pages:1129-1135
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Abstract

The aim of the present study was to assess the neuroprotective effect of berberine against learning and memory deficits in diffuse axonal injury (DAI). DAI rats were orally gavaged with berberine at a dose of 200 mg/kg of body weight for 4 weeks. Behavioral tests were used to analyze the neuroprotective effect of berberine against DAI‑induced learning and memory deficits. In the present study, treatment with berberine significantly protected against DAI‑induced inhibition of learning and memory in rats. Notably, berberine significantly suppressed the levels of tumor necrosis factor, interleukin‑1β and monocyte chemoattractant protein‑1, as well as reduced the protein expression levels of nuclear factor‑κB, Bcl‑2‑associated X protein and cytochrome c in DAI rats. In addition, berberine significantly suppressed the protein expression of p38 mitogen‑activated protein kinase, activating transcription factor 2 and vascular endothelial growth factor in DAI rats. These results suggested that berberine exhibited a neuroprotective effect against learning and memory deficits in severe DAI through the suppression of inflammation, angiogenesis and apoptosis in a rat model.

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January 2018
Volume 15 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
Wang, H., Wang, B., Chen, M., Chen, H., Sun, C., Shen, G., & Zhang, J. (2018). Neuroprotective effect of berberine against learning and memory deficits in diffuse axonal injury. Experimental and Therapeutic Medicine, 15, 1129-1135. https://doi.org/10.3892/etm.2017.5496
MLA
Wang, H., Wang, B., Chen, M., Chen, H., Sun, C., Shen, G., Zhang, J."Neuroprotective effect of berberine against learning and memory deficits in diffuse axonal injury". Experimental and Therapeutic Medicine 15.1 (2018): 1129-1135.
Chicago
Wang, H., Wang, B., Chen, M., Chen, H., Sun, C., Shen, G., Zhang, J."Neuroprotective effect of berberine against learning and memory deficits in diffuse axonal injury". Experimental and Therapeutic Medicine 15, no. 1 (2018): 1129-1135. https://doi.org/10.3892/etm.2017.5496