Association of long non‑coding RNA GAS5 and miR‑21 levels in CD4+ T cells with clinical features of systemic lupus erythematosus

  • Authors:
    • Qi‑Feng Suo
    • Jun Sheng
    • Fu‑Yong Qiang
    • Zong‑Sheng Tang
    • Ying‑Ying Yang
  • View Affiliations

  • Published online on: November 1, 2017     https://doi.org/10.3892/etm.2017.5429
  • Pages:345-350
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Abstract

The present study aimed to assess the expression of growth arrest‑specific 5 (GAS5) and microRNA (miR)‑21 in systemic lupus erythematosus (SLE), and attempted to explore their association with clinical features. CD4+ T cells were isolated from peripheral blood of healthy donors and SLE patients by magnetic‑activated cell sorting. GAS5 and miR‑21 expression levels in cluster of differentiation (CD)4+ T cells were measured by reverse‑transcription quantitative polymerase chain reaction. The results revealed that GAS5 and miR‑21 levels were significantly elevated in CD4+ T cells of patients with SLE compared with those in control subjects (P<0.05). Regarding clinical features, SLE patients with ulceration had higher GAS5 expression levels in CD4+ T cells than those without ulceration (P<0.05), and the expression of miR‑21 was significantly higher in CD4+ T cells of SLE patients with low levels of complement component 3 (C3) than in those with normal levels of complement C3 (P<0.05). In conclusion, GAS5 and miR‑21 in CD4+ T cells may serve as potential biomarkers for the diagnosis and monitoring of the progression of SLE.

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January 2018
Volume 15 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
Suo, Q., Sheng, J., Qiang, F., Tang, Z., & Yang, Y. (2018). Association of long non‑coding RNA GAS5 and miR‑21 levels in CD4+ T cells with clinical features of systemic lupus erythematosus. Experimental and Therapeutic Medicine, 15, 345-350. https://doi.org/10.3892/etm.2017.5429
MLA
Suo, Q., Sheng, J., Qiang, F., Tang, Z., Yang, Y."Association of long non‑coding RNA GAS5 and miR‑21 levels in CD4+ T cells with clinical features of systemic lupus erythematosus". Experimental and Therapeutic Medicine 15.1 (2018): 345-350.
Chicago
Suo, Q., Sheng, J., Qiang, F., Tang, Z., Yang, Y."Association of long non‑coding RNA GAS5 and miR‑21 levels in CD4+ T cells with clinical features of systemic lupus erythematosus". Experimental and Therapeutic Medicine 15, no. 1 (2018): 345-350. https://doi.org/10.3892/etm.2017.5429