Open Access

The protective effects of GYY4137 on ipsilateral testicular injury in experimentally varicocele‑induced rats

  • Authors:
    • Jin‑Zhuo Ning
    • Wei Li
    • Fan Cheng
    • Ting Rao
    • Wei‑Min Yu
    • Yuan Ruan
    • Run Yuan
    • Xiao‑Bin Zhang
    • Yang Du
    • Cheng‑Cheng Xiao
  • View Affiliations

  • Published online on: November 1, 2017     https://doi.org/10.3892/etm.2017.5417
  • Pages:433-439
  • Copyright: © Ning et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to evaluate whether morpholin‑4‑ium 4 methoxyphenyl (morpholino) phosphonodithioate (GYY4137) exhibits a protective effect on ipsilateral testicular injury in experimentally varicocele (VC)‑induced rats. A total of 48 rats were randomly divided into the following 6 groups (n=8 each): Group A (control group); group B (sham group); group C (VC group); group D (VC group administered 5 mg/kg/day GYY4137); group E (VC group administered 10 mg/kg/day GYY4137) and group F (VC group administered 20 mg/kg/day GYY4137). Indicators of oxidative stress, apoptosis and inflammation were measured to evaluate the effect of GYY4137 on ipsilateral testicular injury. Compared with groups A and B, rats in group C exhibited severe histological changes and an increase in oxidative stress, apoptosis and inflammation. By contrast, amelioration of testicular damage was evident in the group D, E and F that were treated with GYY4137. These results demonstrate that GYY4137 may be a promising therapy to treat VC as it alleviates oxidative stress, apoptosis and inflammation in experimentally VC‑induced rats.

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January 2018
Volume 15 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
Ning, J., Li, W., Cheng, F., Rao, T., Yu, W., Ruan, Y. ... Xiao, C. (2018). The protective effects of GYY4137 on ipsilateral testicular injury in experimentally varicocele‑induced rats. Experimental and Therapeutic Medicine, 15, 433-439. https://doi.org/10.3892/etm.2017.5417
MLA
Ning, J., Li, W., Cheng, F., Rao, T., Yu, W., Ruan, Y., Yuan, R., Zhang, X., Du, Y., Xiao, C."The protective effects of GYY4137 on ipsilateral testicular injury in experimentally varicocele‑induced rats". Experimental and Therapeutic Medicine 15.1 (2018): 433-439.
Chicago
Ning, J., Li, W., Cheng, F., Rao, T., Yu, W., Ruan, Y., Yuan, R., Zhang, X., Du, Y., Xiao, C."The protective effects of GYY4137 on ipsilateral testicular injury in experimentally varicocele‑induced rats". Experimental and Therapeutic Medicine 15, no. 1 (2018): 433-439. https://doi.org/10.3892/etm.2017.5417