Open Access

Predicting the visual acuity for retinal vein occlusion after ranibizumab therapy with an original ranking for macular microstructure

  • Authors:
    • Haiyang Liu
    • Suyan Li
    • Zhengpei Zhang
    • Jie Shen
  • View Affiliations

  • Published online on: November 3, 2017     https://doi.org/10.3892/etm.2017.5437
  • Pages:890-896
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The study investigated predictive factors for best‑corrected visual acuity (BCVA) after ranibizumab treatment in patients with macular edema (ME) associated with retinal vein occlusion (RVO) with an original ranking for the impairment of macular microstructure. In this retrospective study, 31 eyes of 31 patients with RVO received 3 monthly consecutive ranibizumab injections and another 3 months of follow‑up. An original method was applied to rank the impairment of the external limiting membrane (ELM) and the ellipsoid zone (previously called the photoreceptor inner and outer segment junction, IS/OS) integrity on the baseline optical coherence tomography (OCT) images. Univariate and multivariate linear regression analyses were performed to assess the association between the baseline factors and post-treatment BCVA. ELM integrity and baseline BCVA were shown to be independent factors in the prediction of post-treatment BCVA. Comparison of post-treatment BCVA between original ELM ranks after adjusting for the baseline BCVA revealed the ELM integrity beneath the center of the fovea was important to post-treatment BCVA. ELM integrity in particular beneath the center of the fovea and baseline BCVA may be more useful than other factors in the prediction of visual function in patients with ME secondary to RVO after ranibizumab injections.

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January 2018
Volume 15 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
Liu, H., Li, S., Zhang, Z., & Shen, J. (2018). Predicting the visual acuity for retinal vein occlusion after ranibizumab therapy with an original ranking for macular microstructure. Experimental and Therapeutic Medicine, 15, 890-896. https://doi.org/10.3892/etm.2017.5437
MLA
Liu, H., Li, S., Zhang, Z., Shen, J."Predicting the visual acuity for retinal vein occlusion after ranibizumab therapy with an original ranking for macular microstructure". Experimental and Therapeutic Medicine 15.1 (2018): 890-896.
Chicago
Liu, H., Li, S., Zhang, Z., Shen, J."Predicting the visual acuity for retinal vein occlusion after ranibizumab therapy with an original ranking for macular microstructure". Experimental and Therapeutic Medicine 15, no. 1 (2018): 890-896. https://doi.org/10.3892/etm.2017.5437