Open Access

Atorvastatin improves coronary flow and endothelial function in patients with coronary slow flow

  • Authors:
    • Hongmei Niu
    • Zhenzhen Wei
    • Yanling Zhang
    • Jian He
    • Danyan Jia
  • View Affiliations

  • Published online on: November 10, 2017     https://doi.org/10.3892/etm.2017.5484
  • Pages:904-908
  • Copyright: © Niu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The underlying mechanisms behind the effect of atorvastatin on patients with coronary slow flow (CSF) remain largely unknown. To investigate the possible underlying molecular mechanisms 108 patients were divided into atorvastatin group and control group. Coronary flow was quantified according to corrected TIMI frame count (CTFC). Serum high sensitivity C-reactive protein (hs-CRP), lipids, ET-1, interleukin (IL)-6, NO, circulating endothelial progenitor cell (cEPC) count, adhesion, migration and proliferation were measured in pretreatment and post-treatment. After respective treatment, the atorvastatin group had significantly decreased levels of TC, TG, LDL-C, hs-CRP, ET-1 and IL-6 and increased NO compared to the control group. The atorvastatin group had a more significant improvement of CTFC, effective rate, cEPC number, EPC adhesion, migration and proliferation compared to the control group. In conclusion, atorvastatin can be used in treatment of CSF by suppressing inflammation and improving endothelial function.

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January 2018
Volume 15 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
Niu, H., Wei, Z., Zhang, Y., He, J., & Jia, D. (2018). Atorvastatin improves coronary flow and endothelial function in patients with coronary slow flow. Experimental and Therapeutic Medicine, 15, 904-908. https://doi.org/10.3892/etm.2017.5484
MLA
Niu, H., Wei, Z., Zhang, Y., He, J., Jia, D."Atorvastatin improves coronary flow and endothelial function in patients with coronary slow flow". Experimental and Therapeutic Medicine 15.1 (2018): 904-908.
Chicago
Niu, H., Wei, Z., Zhang, Y., He, J., Jia, D."Atorvastatin improves coronary flow and endothelial function in patients with coronary slow flow". Experimental and Therapeutic Medicine 15, no. 1 (2018): 904-908. https://doi.org/10.3892/etm.2017.5484