Open Access

Paclitaxel inhibits breast cancer metastasis via suppression of Aurora kinase‑mediated cofilin‑1 activity

  • Authors:
    • Yue Zhang
    • Yaoyi Wang
    • Jun Xue
  • View Affiliations

  • Published online on: December 1, 2017     https://doi.org/10.3892/etm.2017.5588
  • Pages:1269-1276
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The main problem in breast cancer treatment is the recurrence of tumor growth and metastases. Previous studies have suggested that Paclitaxel is widely used to treat various cancers. The present study analyzed the potential signaling pathway of Paclitaxel‑inhibited breast cancer metastasis. It was demonstrated that Paclitaxel treatment significantly inhibited growth of breast cancer cell lines including MCF‑7 and SKBR3 cells. Results demonstrated that Paclitaxel significantly inhibited breast cancer cell migration and invasion. Results additionally demonstrated that Paclitaxel treatment suppressed Aurora kinase and cofilin‑1 activity in breast cancer cells. The potential mechanism indicated that activation of Aurora kinase activity stimulated cofilin‑1 activity, which canceled Paclitaxel‑inhibited growth and aggressiveness of breast cancer cells. An in vivo assay revealed that Paclitaxel treatment significantly inhibited breast cancer growth. Immunohistochemistry demonstrated that Paclitaxel treatment increased apoptosis of tumor cells in tumor tissue. Notably, Aurora kinase and cofilin‑1 activity were downregulated by Paclitaxel in tumor tissues. In conclusion, these results indicated that Paclitaxel inhibited breast cancer cell growth and metastasis via suppression of Aurora kinase‑mediated cofilin‑1 activity, suggesting Paclitaxel may be an efficient anticancer agent for the treatment of this disease.

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February 2018
Volume 15 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
(total number of cites)

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APA
Zhang, Y., Wang, Y., & Xue, J. (2018). Paclitaxel inhibits breast cancer metastasis via suppression of Aurora kinase‑mediated cofilin‑1 activity. Experimental and Therapeutic Medicine, 15, 1269-1276. https://doi.org/10.3892/etm.2017.5588
MLA
Zhang, Y., Wang, Y., Xue, J."Paclitaxel inhibits breast cancer metastasis via suppression of Aurora kinase‑mediated cofilin‑1 activity". Experimental and Therapeutic Medicine 15.2 (2018): 1269-1276.
Chicago
Zhang, Y., Wang, Y., Xue, J."Paclitaxel inhibits breast cancer metastasis via suppression of Aurora kinase‑mediated cofilin‑1 activity". Experimental and Therapeutic Medicine 15, no. 2 (2018): 1269-1276. https://doi.org/10.3892/etm.2017.5588