Efficacy of salmeterol and formoterol combination treatment in mice with chronic obstructive pulmonary disease

  • Authors:
    • Zhiyuan Wang
    • Chunyan Wang
    • Xiaoli Yang
  • View Affiliations

  • Published online on: November 24, 2017     https://doi.org/10.3892/etm.2017.5562
  • Pages:1538-1545
Metrics: HTML 0 views | PDF 0 views     Cited By (CrossRef): 0 citations

Abstract

Chronic obstructive pulmonary disease (COPD) is a severe lung disease characterized by progressive airflow limitation. Salmeterol and formoterol are two commonly used drugs in COPD therapy, which act as β2‑receptor agonists. In the current study, a mouse model of COPD induced by airway lipopolysaccharide inhalation was established. The therapeutic efficacy of salmeterol and formoterol co‑treatment was investigated in this model over a 56‑day‑long observation period. It was also identified that functional residual capacity and inspiratory resistance were significantly improved after salmeterol and/or formoterol treatment compared with the control group (all P<0.01). Furthermore, histological staining of lung tissue samples indicated that inflammation, thickening of the smooth muscle, goblet cell hyperplasia and pulmonary small vessel obstruction were reduced in the mice treated with salmeterol and/or formoterol, suggesting that salmeterol and formoterol were beneficial for ongoing airway and blood vessel remodeling in mice with COPD. The most common treatment‑associated adverse events were hypertension and proteinuria. In conclusion, combined salmeterol and formoterol treatment was more effective compared with either single agent, suggesting that salmeterol and formoterol combined treatment has therapeutic value for the clinical treatment of patients with COPD.

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February 2018
Volume 15 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
Wang, Z., Wang, C., & Yang, X. (2018). Efficacy of salmeterol and formoterol combination treatment in mice with chronic obstructive pulmonary disease. Experimental and Therapeutic Medicine, 15, 1538-1545. https://doi.org/10.3892/etm.2017.5562
MLA
Wang, Z., Wang, C., Yang, X."Efficacy of salmeterol and formoterol combination treatment in mice with chronic obstructive pulmonary disease". Experimental and Therapeutic Medicine 15.2 (2018): 1538-1545.
Chicago
Wang, Z., Wang, C., Yang, X."Efficacy of salmeterol and formoterol combination treatment in mice with chronic obstructive pulmonary disease". Experimental and Therapeutic Medicine 15, no. 2 (2018): 1538-1545. https://doi.org/10.3892/etm.2017.5562