A pilot study of a cardiovascular virtual endoscopy system based on multi‑detector computed tomography in diagnosing tetralogy of Fallot in pediatric patients

  • Authors:
    • Li‑Ping Yao
    • Li Zhang
    • Ju Mei
    • Fang‑Bao Ding
    • Hui‑Ming Li
    • Ming Ding
    • Xin Yang
    • Xiao‑Ming Li
    • Kun Sun
  • View Affiliations

  • Published online on: November 27, 2017     https://doi.org/10.3892/etm.2017.5572
  • Pages:1552-1559
Metrics: HTML 0 views | PDF 0 views     Cited By (CrossRef): 0 citations

Abstract

The present study aimed to investigate the capabilities of the cardiovascular virtual endoscopy (VE) system in diagnosing tetralogy of Fallot (TOF) and performing measurements. A total of 37 patients underwent two‑dimensional echocardiography (2‑DE) and multi‑detector computed tomography (MDCT) examinations. The obtained MDCT images were applied to a cardiovascular VE system. Diagnostic time by VE was first studied and compared with MDCT. Subsequently, with surgical findings as the ground truth, the capabilities of VE, 2‑DE and MDCT in diagnosing TOF and its complications were investigated. Additionally, measurements on aorta overriding ratio and diameters for the left pulmonary artery, right pulmonary artery and right ventricular outflow tract by 2‑DE and VE were analyzed. Diagnostic time by VE was significantly shorter than MDCT (188±42 vs. 303±42 sec, respectively; P<0.0001). VE, MDCT and 2‑DE demonstrated comparable diagnostic rates of TOF (35/37 vs. 34/37 vs. 32/37, respectively; P>0.05). Similar findings were demonstrated in diagnosing complications of the muscular ventricular septal defects, patent ductus arteriosus, vagus subclavian artery, right arch, double superior vena cava and pulmonary artery. Furthermore, in diagnosing the atrial septal defect, 2‑DE outperformed MDCT and VE (accuracy, 100 vs. 81 vs. 73%, respectively; all P<0.05). In performing relevant measurements, VE outperformed MDCT and 2‑DE, particularly in accessing aorta overriding ratios with no intra‑operator difference (P=0.3770) and high consistency (r=0.916). In conclusion, cardiovascular VE was demonstrated to have acceptable accuracy in diagnosing TOF, and possess advantages in shortening the diagnostic time and in performing measurements.

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February 2018
Volume 15 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
Yao, L., Zhang, L., Mei, J., Ding, F., Li, H., Ding, M. ... Sun, K. (2018). A pilot study of a cardiovascular virtual endoscopy system based on multi‑detector computed tomography in diagnosing tetralogy of Fallot in pediatric patients. Experimental and Therapeutic Medicine, 15, 1552-1559. https://doi.org/10.3892/etm.2017.5572
MLA
Yao, L., Zhang, L., Mei, J., Ding, F., Li, H., Ding, M., Yang, X., Li, X., Sun, K."A pilot study of a cardiovascular virtual endoscopy system based on multi‑detector computed tomography in diagnosing tetralogy of Fallot in pediatric patients". Experimental and Therapeutic Medicine 15.2 (2018): 1552-1559.
Chicago
Yao, L., Zhang, L., Mei, J., Ding, F., Li, H., Ding, M., Yang, X., Li, X., Sun, K."A pilot study of a cardiovascular virtual endoscopy system based on multi‑detector computed tomography in diagnosing tetralogy of Fallot in pediatric patients". Experimental and Therapeutic Medicine 15, no. 2 (2018): 1552-1559. https://doi.org/10.3892/etm.2017.5572