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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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February-2018 Volume 15 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Anti-depressant-like effect of atractylenolide I in a mouse model of depression induced by chronic unpredictable mild stress

  • Authors:
    • Haiyan Gao
    • Xianghua Zhu
    • Yang Xi
    • Qun Li
    • Zhenzhong Shen
    • Yongjie Yang

  • View Affiliations / Copyright

    Affiliations: Department of Psychiatry, Xuzhou Oriental People's Hospital, Xuzhou, Jiangsu 221004, P.R. China
  • Pages: 1574-1579
    |
    Published online on: November 16, 2017
       https://doi.org/10.3892/etm.2017.5517
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Abstract

Atractylenolide I (AT‑I), a major component of the rhizoma of Atractylodes macrocephala Koidz., exerts a wide range of activities. The purpose of the present study was to investigate the anti‑depressant‑like effect of AT‑I in a mouse model of chronic unpredictable mild stress (CUMS), and to explore the possible molecular mechanism involved. It was revealed that AT‑I significantly ameliorated CUMS‑induced depressive‑like behaviors, as evidenced by increased sucrose preference as well as shortened immobility time in the forced swimming and the tail suspension test. In addition, AT‑I reduced CUMS‑induced decreases in the concentrations of serotonin and norepinephrine in the hippocampus. Furthermore, AT‑I inhibited the activation of the nucleotide binding and oligomerization domain‑like receptor family pyrin domain‑containing 3 (NLRP3) inflammasome as well as the concentration of the pro‑inflammatory cytokine interleukin (IL)‑1β in the hippocampi of mice subjected to CUMS. In conclusion, the results of the present study suggested that AT‑I exerts anti‑depressant‑like effects in a CUMS‑induced model of depression in mice, the molecular mechanism of which is associated with the inhibition of NLRP3 inflammasome activation to decrease IL‑1β production.

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Copy and paste a formatted citation
Spandidos Publications style
Gao H, Zhu X, Xi Y, Li Q, Shen Z and Yang Y: Anti-depressant-like effect of atractylenolide I in a mouse model of depression induced by chronic unpredictable mild stress. Exp Ther Med 15: 1574-1579, 2018.
APA
Gao, H., Zhu, X., Xi, Y., Li, Q., Shen, Z., & Yang, Y. (2018). Anti-depressant-like effect of atractylenolide I in a mouse model of depression induced by chronic unpredictable mild stress. Experimental and Therapeutic Medicine, 15, 1574-1579. https://doi.org/10.3892/etm.2017.5517
MLA
Gao, H., Zhu, X., Xi, Y., Li, Q., Shen, Z., Yang, Y."Anti-depressant-like effect of atractylenolide I in a mouse model of depression induced by chronic unpredictable mild stress". Experimental and Therapeutic Medicine 15.2 (2018): 1574-1579.
Chicago
Gao, H., Zhu, X., Xi, Y., Li, Q., Shen, Z., Yang, Y."Anti-depressant-like effect of atractylenolide I in a mouse model of depression induced by chronic unpredictable mild stress". Experimental and Therapeutic Medicine 15, no. 2 (2018): 1574-1579. https://doi.org/10.3892/etm.2017.5517
Copy and paste a formatted citation
x
Spandidos Publications style
Gao H, Zhu X, Xi Y, Li Q, Shen Z and Yang Y: Anti-depressant-like effect of atractylenolide I in a mouse model of depression induced by chronic unpredictable mild stress. Exp Ther Med 15: 1574-1579, 2018.
APA
Gao, H., Zhu, X., Xi, Y., Li, Q., Shen, Z., & Yang, Y. (2018). Anti-depressant-like effect of atractylenolide I in a mouse model of depression induced by chronic unpredictable mild stress. Experimental and Therapeutic Medicine, 15, 1574-1579. https://doi.org/10.3892/etm.2017.5517
MLA
Gao, H., Zhu, X., Xi, Y., Li, Q., Shen, Z., Yang, Y."Anti-depressant-like effect of atractylenolide I in a mouse model of depression induced by chronic unpredictable mild stress". Experimental and Therapeutic Medicine 15.2 (2018): 1574-1579.
Chicago
Gao, H., Zhu, X., Xi, Y., Li, Q., Shen, Z., Yang, Y."Anti-depressant-like effect of atractylenolide I in a mouse model of depression induced by chronic unpredictable mild stress". Experimental and Therapeutic Medicine 15, no. 2 (2018): 1574-1579. https://doi.org/10.3892/etm.2017.5517
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