Anti-depressant-like effect of atractylenolide I in a mouse model of depression induced by chronic unpredictable mild stress

  • Authors:
    • Haiyan Gao
    • Xianghua Zhu
    • Yang Xi
    • Qun Li
    • Zhenzhong Shen
    • Yongjie Yang
  • View Affiliations

  • Published online on: November 16, 2017     https://doi.org/10.3892/etm.2017.5517
  • Pages:1574-1579
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Abstract

Atractylenolide I (AT‑I), a major component of the rhizoma of Atractylodes macrocephala Koidz., exerts a wide range of activities. The purpose of the present study was to investigate the anti‑depressant‑like effect of AT‑I in a mouse model of chronic unpredictable mild stress (CUMS), and to explore the possible molecular mechanism involved. It was revealed that AT‑I significantly ameliorated CUMS‑induced depressive‑like behaviors, as evidenced by increased sucrose preference as well as shortened immobility time in the forced swimming and the tail suspension test. In addition, AT‑I reduced CUMS‑induced decreases in the concentrations of serotonin and norepinephrine in the hippocampus. Furthermore, AT‑I inhibited the activation of the nucleotide binding and oligomerization domain‑like receptor family pyrin domain‑containing 3 (NLRP3) inflammasome as well as the concentration of the pro‑inflammatory cytokine interleukin (IL)‑1β in the hippocampi of mice subjected to CUMS. In conclusion, the results of the present study suggested that AT‑I exerts anti‑depressant‑like effects in a CUMS‑induced model of depression in mice, the molecular mechanism of which is associated with the inhibition of NLRP3 inflammasome activation to decrease IL‑1β production.

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February 2018
Volume 15 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
Gao, H., Zhu, X., Xi, Y., Li, Q., Shen, Z., & Yang, Y. (2018). Anti-depressant-like effect of atractylenolide I in a mouse model of depression induced by chronic unpredictable mild stress. Experimental and Therapeutic Medicine, 15, 1574-1579. https://doi.org/10.3892/etm.2017.5517
MLA
Gao, H., Zhu, X., Xi, Y., Li, Q., Shen, Z., Yang, Y."Anti-depressant-like effect of atractylenolide I in a mouse model of depression induced by chronic unpredictable mild stress". Experimental and Therapeutic Medicine 15.2 (2018): 1574-1579.
Chicago
Gao, H., Zhu, X., Xi, Y., Li, Q., Shen, Z., Yang, Y."Anti-depressant-like effect of atractylenolide I in a mouse model of depression induced by chronic unpredictable mild stress". Experimental and Therapeutic Medicine 15, no. 2 (2018): 1574-1579. https://doi.org/10.3892/etm.2017.5517