MAPK pathway mediates the anti‑oxidative effect of chicoric acid against cerebral ischemia‑reperfusion injury in vivo

  • Authors:
    • Linwei Jia
    • Yonghan Chen
    • Yao‑Hui Tian
    • Gang Zhang
  • View Affiliations

  • Published online on: December 5, 2017     https://doi.org/10.3892/etm.2017.5598
  • Pages:1640-1646
Metrics: HTML 0 views | PDF 0 views     Cited By (CrossRef): 0 citations

Abstract

The aim of the present study was to investigate the protective effect of chicoric acid on oxidative stress and inflammation in rats with cerebral ischemia‑reperfusion injury. A cerebral ischemia‑reperfusion injury rat model was created via transient middle cerebral artery occlusion (MCAO) and rats were treated with various doses of chicoric acid (0, 1, 10 and 100 mg/kg). Neurological deficits and infarct volume were used to estimate the protective effects of chicoric acid treatment. Levels of reactive oxygen species (ROS), tumor necrosis factor‑α (TNF‑α), interleukin (IL)‑1β, nitric oxide (NO) and prostaglandin E2 (PGE2) were assessed. Western blot analysis was also used to measure the expression of cyclooxygenase (COX)‑2, p38‑mitogen activated protein kinase (MAPK), c‑Jun, phosphorylated protein kinase B (p‑AKT) and AKT. Chicoric acid exposure was observed to reduce neurological deficits and infarct volume in rats with cerebral ischemia‑reperfusion injury. In addition, ROS production and inflammation were significantly suppressed following treatment with chicoric acid. Chicoric acid was demonstrated to significantly inhibit the upregulation of NO and PGE2 levels in rats following MCAO. Furthermore, chicoric acid significantly suppressed the MCAO‑induced promotion of COX‑2, p38‑MAPK and c‑Jun protein expression and enhanced the inhibition of p‑AKT/AKT. These results suggest that chicoric acid has a protective effect, preventing oxidative stress and inflammation in rats with cerebral ischemia‑reperfusion injury via the p38‑MAPK, c‑Jun and AKT signaling pathways.

Related Articles

Journal Cover

February 2018
Volume 15 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Jia, L., Chen, Y., Tian, Y., & Zhang, G. (2018). MAPK pathway mediates the anti‑oxidative effect of chicoric acid against cerebral ischemia‑reperfusion injury in vivo. Experimental and Therapeutic Medicine, 15, 1640-1646. https://doi.org/10.3892/etm.2017.5598
MLA
Jia, L., Chen, Y., Tian, Y., Zhang, G."MAPK pathway mediates the anti‑oxidative effect of chicoric acid against cerebral ischemia‑reperfusion injury in vivo". Experimental and Therapeutic Medicine 15.2 (2018): 1640-1646.
Chicago
Jia, L., Chen, Y., Tian, Y., Zhang, G."MAPK pathway mediates the anti‑oxidative effect of chicoric acid against cerebral ischemia‑reperfusion injury in vivo". Experimental and Therapeutic Medicine 15, no. 2 (2018): 1640-1646. https://doi.org/10.3892/etm.2017.5598