Smoking increases the risk of diabetic foot amputation: A meta-analysis

  • Authors:
    • Min Liu
    • Wei Zhang
    • Zhaoli Yan
    • Xiangzhen Yuan
  • View Affiliations

  • Published online on: November 22, 2017     https://doi.org/10.3892/etm.2017.5538
  • Pages:1680-1685
Metrics: HTML 0 views | PDF 0 views     Cited By: 0 citations

Abstract

Accumulating evidence suggests that smoking is associated with diabetic foot amputation. However, the currently available results are inconsistent and controversial. Therefore, the present study performed a meta‑analysis to systematically review the association between smoking and diabetic foot amputation and to investigate the risk factors of diabetic foot amputation. Public databases, including PubMed and Embase, were searched prior to 29th February 2016. The heterogeneity was assessed using the Cochran's Q statistic and the I2 statistic, and odds ratio (OR) and 95% confidence interval (CI) were calculated and pooled appropriately. Sensitivity analysis was performed to evaluate the stability of the results. In addition, Egger's test was applied to assess any potential publication bias. Based on the research, a total of eight studies, including five cohort studies and three case control studies were included. The data indicated that smoking significantly increased the risk of diabetic foot amputation (OR=1.65; 95% CI, 1.09‑2.50; P<0.0001) compared with non‑smoking. Sensitivity analysis demonstrated that the pooled analysis did not vary substantially following the exclusion of any one study. Additionally, there was no evidence of publication bias (Egger's test, t=0.1378; P=0.8958). Furthermore, no significant difference was observed between the minor and major amputation groups in patients who smoked (OR=0.79; 95% CI, 0.24‑2.58). The results of the present meta‑analysis suggested that smoking is a notable risk factor for diabetic foot amputation. Smoking cessation appears to reduce the risk of diabetic foot amputation.

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February 2018
Volume 15 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
Liu, M., Zhang, W., Yan, Z., & Yuan, X. (2018). Smoking increases the risk of diabetic foot amputation: A meta-analysis . Experimental and Therapeutic Medicine, 15, 1680-1685. https://doi.org/10.3892/etm.2017.5538
MLA
Liu, M., Zhang, W., Yan, Z., Yuan, X."Smoking increases the risk of diabetic foot amputation: A meta-analysis ". Experimental and Therapeutic Medicine 15.2 (2018): 1680-1685.
Chicago
Liu, M., Zhang, W., Yan, Z., Yuan, X."Smoking increases the risk of diabetic foot amputation: A meta-analysis ". Experimental and Therapeutic Medicine 15, no. 2 (2018): 1680-1685. https://doi.org/10.3892/etm.2017.5538