Protective effects of resveratrol improve cardiovascular function in rats with diabetes

  • Authors:
    • Fuqin Yan
    • Xiaomeng Sun
    • Chun Xu
  • View Affiliations

  • Published online on: November 22, 2017     https://doi.org/10.3892/etm.2017.5537
  • Pages: 1728-1734
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Abstract

Resveratrol is a flavonoid with a stilbene structure that is able to suppress acute pulmonary thromboembolism‑induced pulmonary artery hypertension. Furthermore, it possesses anti‑cancer and antioxidant properties, is able to regulate blood lipids and increase life expectancy. In the present study, it was evaluated whether the protective effect of resveratrol was able to improve cardiovascular function in rats with diabetes. The effects of resveratrol on blood glucose, body weight, heart/body weight ratio, plasma triglyceride levels, heart rate, aspartate transaminase (AST)/alanine transaminase (ALT) ratio and total plasma insulin were evaluated. Levels of inflammation and oxidative stress were also evaluated using ELISA kits, and the expressions of endothelial nitric oxide synthase (eNOS), vascular endothelial growth factor (VEGF) and phosphorylated (p)‑p38 protein were evaluated via western blot analysis. The results demonstrated that administration of resveratrol in rats with diabetes‑related myocardial infarction (DRMI) significantly reduced blood glucose, body weight, plasma triglyceride levels, heart rate and AST/ALT ratio (all P<0.01) and significantly increased total plasma insulin (P<0.01). Furthermore, resveratrol significantly reduced levels of inflammation factors (P<0.01) and malondialdehyde, a marker for oxidative stress, in rats with DRMI (P<0.01). Resveratrol significantly increased the expression of eNOS (P<0.01) and suppressed the expression of VEGF and p‑p38 (both P<0.01) in rats with DRMI. These results suggest that treatment with resveratrol is able to improve cardiovascular function via inhibition of eNOS and VEGF, and suppression of p38 phosphorylation in rats with DRMI.

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February 2018
Volume 15 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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APA
Yan, F., Sun, X., & Xu, C. (2018). Protective effects of resveratrol improve cardiovascular function in rats with diabetes. Experimental and Therapeutic Medicine, 15, 1728-1734. https://doi.org/10.3892/etm.2017.5537
MLA
Yan, F., Sun, X., Xu, C."Protective effects of resveratrol improve cardiovascular function in rats with diabetes". Experimental and Therapeutic Medicine 15.2 (2018): 1728-1734.
Chicago
Yan, F., Sun, X., Xu, C."Protective effects of resveratrol improve cardiovascular function in rats with diabetes". Experimental and Therapeutic Medicine 15, no. 2 (2018): 1728-1734. https://doi.org/10.3892/etm.2017.5537