Open Access

Pediatric acute respiratory distress syndrome - current views (Review)

  • Authors:
    • Jinfeng Liu
    • Wei Wang
    • Fengli Liu
    • Zhenguang Li
  • View Affiliations

  • Published online on: December 14, 2017     https://doi.org/10.3892/etm.2017.5628
  • Pages:1775-1780
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Acute respiratory distress syndrome (ARDS) mainly involves acute respiratory failure. In addition to this affected patients feel progressive arterial hypoxemia, dyspnea, and a marked increase in the work of breathing. The only clinical solution for the above pathological state is ventilation. Mechanical ventilation is necessary to support life in ARDs but it itself worsen lung injury and the term is known clinically as ‘ventilation induced lung injury’ (VILI). At the cellular level, respiratory epithelial cells are subjected to cyclic stretch, i.e. repeated cycles of positive and negative strain, during normal tidal ventilation. In aerated areas of diseased lungs, or even normal lungs subjected to injurious positive pressure mechanical ventilation, the cells are at risk of being over distended, and worsening injury by disrupting the alveolar epithelial barrier. Further, hypercapnic acidosis (HCA) in itself confers protection from stretch injury, potentially via a mechanisms involving inhibition of nuclear factor κB (NF-κB), a transcription factor central to inflammation, injury and repair. Mesenchymal stem cells are the latest in the field and are being investigated as a possible therapy for ARDS.

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February 2018
Volume 15 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
APA
Liu, J., Wang, W., Liu, F., & Li, Z. (2018). Pediatric acute respiratory distress syndrome - current views (Review). Experimental and Therapeutic Medicine, 15, 1775-1780. https://doi.org/10.3892/etm.2017.5628
MLA
Liu, J., Wang, W., Liu, F., Li, Z."Pediatric acute respiratory distress syndrome - current views (Review)". Experimental and Therapeutic Medicine 15.2 (2018): 1775-1780.
Chicago
Liu, J., Wang, W., Liu, F., Li, Z."Pediatric acute respiratory distress syndrome - current views (Review)". Experimental and Therapeutic Medicine 15, no. 2 (2018): 1775-1780. https://doi.org/10.3892/etm.2017.5628