Open Access

Cyanidin ameliorates cisplatin-induced cardiotoxicity via inhibition of ROS-mediated apoptosis

  • Authors:
    • Peng Qian
    • Li‑Jie Yan
    • Yong‑Qiang Li
    • Hai‑Tao Yang
    • Hong‑Yan Duan
    • Jin‑Tao Wu
    • Xian‑Wei Fan
    • Shan-Ling Wang
  • View Affiliations

  • Published online on: December 12, 2017     https://doi.org/10.3892/etm.2017.5617
  • Pages:1959-1965
  • Copyright: © Qian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Oxidative stress and apoptosis serve an essential role in cisplatin‑induced cardiotoxicity, which limits its clinical use, and increases the risk of cardiovascular disease. As a natural drug, the antioxidant and antitumor effects of cyanidin have been recognized, but its protective effect on cisplatin‑induced cardiomyocyte cytotoxicity remains unclear. H9c2 cells were treated with cisplatin (1‑40 µM) in the presence or absence of cyanidin (40‑80 µM), subsequently; oxidative stress, apoptosis and mitochondrial function were assessed using several techniques. The results demonstrated that cyanidin was able to dose‑dependently reverse cisplatin‑induced cell damage and apoptosis, attenuate the accumulation of reactive oxygen species (ROS), and mitochondrial membrane potential depolarization, downregulate the expression of Bcl‑2 homologous antagonist/killer, upregulate the expression of apoptosis regulator Bcl‑2, and reduce the activation of caspase 3, caspase 9, but not caspase 8. Furthermore, the results revealed that the translocation of apoptosis regulator Bax (Bax) from the cytoplasm to the mitochondrial membrane serves an essential role in cisplatin‑induced apoptosis. Cyanidin was able to block the translocation of Bax and reduce the release of cytochrome c from cytoplasm. These data indicate that cyanidin attenuates cisplatin‑induced cardiotoxicity by inhibiting ROS‑mediated apoptosis, while the mitochondrial and extracellular regulated kinase signaling pathways may also serve important roles.

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February 2018
Volume 15 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
Qian, P., Yan, L., Li, Y., Yang, H., Duan, H., Wu, J. ... Wang, S. (2018). Cyanidin ameliorates cisplatin-induced cardiotoxicity via inhibition of ROS-mediated apoptosis. Experimental and Therapeutic Medicine, 15, 1959-1965. https://doi.org/10.3892/etm.2017.5617
MLA
Qian, P., Yan, L., Li, Y., Yang, H., Duan, H., Wu, J., Fan, X., Wang, S."Cyanidin ameliorates cisplatin-induced cardiotoxicity via inhibition of ROS-mediated apoptosis". Experimental and Therapeutic Medicine 15.2 (2018): 1959-1965.
Chicago
Qian, P., Yan, L., Li, Y., Yang, H., Duan, H., Wu, J., Fan, X., Wang, S."Cyanidin ameliorates cisplatin-induced cardiotoxicity via inhibition of ROS-mediated apoptosis". Experimental and Therapeutic Medicine 15, no. 2 (2018): 1959-1965. https://doi.org/10.3892/etm.2017.5617