Open Access

Efficacy and safety of combined immunosuppressive therapy plus umbilical cord blood infusion in severe aplastic anemia patients: A cohort study

  • Authors:
    • Xiu Luo
    • Huina Lu
    • Bing Xiu
    • Hao Wu
    • Bing Li
    • Ping Li
    • Yuhua Chen
    • Lili Zhou
    • Wenjun Zhang
    • Yan Dong
    • Aibin Liang
    • Yi Ding
  • View Affiliations

  • Published online on: December 12, 2017     https://doi.org/10.3892/etm.2017.5616
  • Pages: 1966-1974
  • Copyright: © Luo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to evaluate the efficacy and safety of combined immunosuppressive therapy (IST) plus umbilical cord blood infusion (UCBI) in severe aplastic anemia (SAA) patients. A total of 68 patients with SAA were enrolled in the current prospective cohort study and divided into the IST (n=35; positive control) and IST+UCBI (n=33; experimental) groups according to the treatment conditions. Patients in the IST group were treated with rabbit antithymocyte globulin (r‑ATG) at a dose of 2.5 mg/kg through intravenous infusion once a day for five days. This was combined with oral cyclosporine A (CsA) at a dose of 3‑5 mg/kg twice a day for 2 years. Patients in the IST+UBCI group were treated with r‑ATG and CsA at the same doses and frequencies as the IST group plus one UCBI 1 day after the final treatment with r‑ATG. At 6 months post treatment, the complete response and overall response rate (ORR) of the IST+UCBI group were markedly higher compared with those in the IST group. Furthermore, patients in the IST+UCBI group achieved absolute neutrophil count (ANC) and platelet count responses more rapidly as compared with the IST group. However, no difference in the hemoglobin (Hb) response was identified between the two groups. In addition, SAA patients achieved responses in the ANC and platelet count more rapidly in comparison with very severe aplastic anemia (VSAA) patients, while the number of days to Hb responses were similar in the SAA and VSAA patients. Multivariate logistic regression analysis also revealed that IST+UCBI treatment was an independent predicting factor for patients achieving complete response or partial response, whereas VSAA was an independent predictor of a worse ORR. Platelet and reticulocyte were also independent predicting factors. Finally, the survival of patients was similar between the groups, and no difference in the safety of the treatment was observed. In conclusion, combined IST plus UCBI treatment may be applied as an effective and safe therapy for SAA patients.

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February 2018
Volume 15 Issue 2

Print ISSN: 1792-0981
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APA
Luo, X., Lu, H., Xiu, B., Wu, H., Li, B., Li, P. ... Ding, Y. (2018). Efficacy and safety of combined immunosuppressive therapy plus umbilical cord blood infusion in severe aplastic anemia patients: A cohort study. Experimental and Therapeutic Medicine, 15, 1966-1974. https://doi.org/10.3892/etm.2017.5616
MLA
Luo, X., Lu, H., Xiu, B., Wu, H., Li, B., Li, P., Chen, Y., Zhou, L., Zhang, W., Dong, Y., Liang, A., Ding, Y."Efficacy and safety of combined immunosuppressive therapy plus umbilical cord blood infusion in severe aplastic anemia patients: A cohort study". Experimental and Therapeutic Medicine 15.2 (2018): 1966-1974.
Chicago
Luo, X., Lu, H., Xiu, B., Wu, H., Li, B., Li, P., Chen, Y., Zhou, L., Zhang, W., Dong, Y., Liang, A., Ding, Y."Efficacy and safety of combined immunosuppressive therapy plus umbilical cord blood infusion in severe aplastic anemia patients: A cohort study". Experimental and Therapeutic Medicine 15, no. 2 (2018): 1966-1974. https://doi.org/10.3892/etm.2017.5616