Open Access

Pine needle oil induces G2/M arrest of HepG2 cells by activating the ATM pathway

  • Authors:
    • Bing Qiu
    • Wei Jiang
    • Wenliang Qiu
    • Wenling Mu
    • Yujing Qin
    • Yongcui Zhu
    • Jianying Zhang
    • Qingyi Wang
    • Dongjie Liu
    • Zhangyi Qu
  • View Affiliations

  • Published online on: December 15, 2017     https://doi.org/10.3892/etm.2017.5648
  • Pages:1975-1981
  • Copyright: © Qiu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Over the last two decades, inducing DNA damage of cancer cells by natural medicines has become a research hotspot in the field of cancer treatment. Although various natural medicines have anticancer effects, very few studies have been conducted to explore the anti‑cancer effect of pine needle oil. In the present study, the role of pine needle oil in inducing G2/M arrest in HepG2 cells was investigated. The data revealed that pine needle oil could induce DNA damage in a dose‑dependent manner. In the pine needle oil‑treated HepG2 cells, the protein levels of phosphorylated (p)-ataxia-telangiectasia mutated (ATM), γ‑H2A histone family, member X, p‑p53, p‑checkpoint kinase 2 and p‑cell division cycle 25C were evidently increased, indicating that pine needle oil facilitated G2/M arrest in HepG2 cells through the ATM pathway. In response to the treatment with pine needle oil, ATM was activated in HepG2 cells, which subsequently phosphorylated downstream targets and induced G2/M arrest. In summary, the data of the present study indicated that pine needle oil induces G2/M arrest in HepG2 cells by facilitating ATM activation.

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Journal Cover

February 2018
Volume 15 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
(total number of cites)

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APA
Qiu, B., Jiang, W., Qiu, W., Mu, W., Qin, Y., Zhu, Y. ... Qu, Z. (2018). Pine needle oil induces G2/M arrest of HepG2 cells by activating the ATM pathway. Experimental and Therapeutic Medicine, 15, 1975-1981. https://doi.org/10.3892/etm.2017.5648
MLA
Qiu, B., Jiang, W., Qiu, W., Mu, W., Qin, Y., Zhu, Y., Zhang, J., Wang, Q., Liu, D., Qu, Z."Pine needle oil induces G2/M arrest of HepG2 cells by activating the ATM pathway". Experimental and Therapeutic Medicine 15.2 (2018): 1975-1981.
Chicago
Qiu, B., Jiang, W., Qiu, W., Mu, W., Qin, Y., Zhu, Y., Zhang, J., Wang, Q., Liu, D., Qu, Z."Pine needle oil induces G2/M arrest of HepG2 cells by activating the ATM pathway". Experimental and Therapeutic Medicine 15, no. 2 (2018): 1975-1981. https://doi.org/10.3892/etm.2017.5648