Open Access

Propofol and sevoflurane combined with remifentanil on the pain index, inflammatory factors and postoperative cognitive function of spine fracture patients

  • Authors:
    • Yu Zhao
    • Hongqi Zhang
  • View Affiliations

  • Published online on: February 27, 2018     https://doi.org/10.3892/etm.2018.5898
  • Pages: 3775-3780
  • Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The effects of propofol vs. sevoflurane combined with remifentanil on the pain index, inflammatory factors and postoperative cognitive function in spine fracture patients were studied and analyzed. A total of 62 patients with vertebral fracture were randomly divided into the propofol group (P group, n=41) and the sevoflurane group (S group, n=41). P group used induction anesthesia with propofol, and maintained anesthesia via intravenous injection of remifentanil. While patients in S group received induction anesthesia with sevoflurane, and also remifentanil as the maintained anesthesia. Results showed that extubation time, eye-opening time and response time of P group were lower than S group (p<0.05). The VAS score 48 h after surgery in P group was significantly lower than the S group (p<0.05). Levels of IL-6, IL-1β, ICAM-1 and MMP-9 in serum in P group were lower than those in S group (p<0.05). Mini-mental state examination (MMSE) score 24 h after surgery in P group was higher than that in S group (p<0.01). Compared with sevoflurane anesthesia, propofol combined with remifentanil anesthesia on spine fracture patients can significantly decrease the pain index and inflammatory reaction, shorten the postoperative recovery time.
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April-2018
Volume 15 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhao Y and Zhao Y: Propofol and sevoflurane combined with remifentanil on the pain index, inflammatory factors and postoperative cognitive function of spine fracture patients. Exp Ther Med 15: 3775-3780, 2018
APA
Zhao, Y., & Zhao, Y. (2018). Propofol and sevoflurane combined with remifentanil on the pain index, inflammatory factors and postoperative cognitive function of spine fracture patients. Experimental and Therapeutic Medicine, 15, 3775-3780. https://doi.org/10.3892/etm.2018.5898
MLA
Zhao, Y., Zhang, H."Propofol and sevoflurane combined with remifentanil on the pain index, inflammatory factors and postoperative cognitive function of spine fracture patients". Experimental and Therapeutic Medicine 15.4 (2018): 3775-3780.
Chicago
Zhao, Y., Zhang, H."Propofol and sevoflurane combined with remifentanil on the pain index, inflammatory factors and postoperative cognitive function of spine fracture patients". Experimental and Therapeutic Medicine 15, no. 4 (2018): 3775-3780. https://doi.org/10.3892/etm.2018.5898