miR-216a-5p acts as an oncogene in renal cell carcinoma

Corrigendum in: /10.3892/etm.2024.12443

  • Authors:
    • Peijie Chen
    • Jing Quan
    • Lu Jin
    • Canbin Lin
    • Weijie Xu
    • Jinling Xu
    • Xin Guan
    • Zebo Chen
    • Liangchao Ni
    • Shangqi Yang
    • Yun Chen
    • Yongqing Lai
  • View Affiliations

  • Published online on: February 20, 2018     https://doi.org/10.3892/etm.2018.5881
  • Pages: 4039-4046
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Abstract

MiR-216a-5p has been acknowledged as an oncogene and is known to be involved in the progression and metastasis of numerous cancer subtypes. However, the potential role of miR‑216a‑5p in renal cell carcinoma (RCC) remains to be elucidated. In the present study, reverse transcription‑quantitative polymerase chain reaction was performed to detect the expression levels of miR‑216a‑5p in RCC tissues. Cell counting kit‑8, MTT, wound scratch, Transwell and flow cytometric assays were performed to establish the biological functions of miR‑216a‑5p in RCC. Functional experiments demonstrated that the expression of miR‑216a‑5p was upregulated in RCC (P<0.05) and miR‑216a‑5p mimics promoted cellular proliferation, viability and motility, and suppressed apoptosis. Conversely, miR‑216a‑5p inhibitor suppressed cellular proliferation, viability, motility and induced apoptosis. Based on these findings, it was concluded that miR‑216a‑5p may function as an oncogene in RCC. MiR‑216a‑5p target genes need to be explored and the potential of miR‑216a‑5p to be used as a diagnostic or a prognostic biomarker for RCC needs to be validated by future research.
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April-2018
Volume 15 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Chen P, Quan J, Jin L, Lin C, Xu W, Xu J, Guan X, Chen Z, Ni L, Yang S, Yang S, et al: miR-216a-5p acts as an oncogene in renal cell carcinoma Corrigendum in /10.3892/etm.2024.12443. Exp Ther Med 15: 4039-4046, 2018
APA
Chen, P., Quan, J., Jin, L., Lin, C., Xu, W., Xu, J. ... Lai, Y. (2018). miR-216a-5p acts as an oncogene in renal cell carcinoma Corrigendum in /10.3892/etm.2024.12443. Experimental and Therapeutic Medicine, 15, 4039-4046. https://doi.org/10.3892/etm.2018.5881
MLA
Chen, P., Quan, J., Jin, L., Lin, C., Xu, W., Xu, J., Guan, X., Chen, Z., Ni, L., Yang, S., Chen, Y., Lai, Y."miR-216a-5p acts as an oncogene in renal cell carcinoma Corrigendum in /10.3892/etm.2024.12443". Experimental and Therapeutic Medicine 15.4 (2018): 4039-4046.
Chicago
Chen, P., Quan, J., Jin, L., Lin, C., Xu, W., Xu, J., Guan, X., Chen, Z., Ni, L., Yang, S., Chen, Y., Lai, Y."miR-216a-5p acts as an oncogene in renal cell carcinoma Corrigendum in /10.3892/etm.2024.12443". Experimental and Therapeutic Medicine 15, no. 4 (2018): 4039-4046. https://doi.org/10.3892/etm.2018.5881