Open Access

Relationship between depression and inflammatory factors and brain-derived neurotrophic factor in patients with perimenopause syndrome

  • Authors:
    • Li Guo
    • Lidong Ren
    • Caixia Zhang
  • View Affiliations

  • Published online on: March 22, 2018     https://doi.org/10.3892/etm.2018.5985
  • Pages: 4436-4440
  • Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The relationship of depression with levels of serum inflammatory factors and brain-derived neurotrophic factor (BDNF) in patients with perimenopausal syndrome was analyzed to investigate the predictive values of risk factors for depression in patients with perimenopausal syndrome. A total of 73 patients with perimenopausal syndrome were selected, and divided into the depression (n=30) and non-depression (n=43) groups. Results showed that the self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores in the depression group were significantly higher than those in the non-depression group (P<0.05). The serum BDNF level in the depression group was significantly lower than that in the non-depression group (P<0.05). The levels of serum inflammatory factors, including C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), in depression group were obviously higher than those in non‑depression group (P<0.05). The correlation analyses of serum inflammatory factor and BDNF levels with depression showed that CRP and TNF-α were positively correlated with SDS score, while BDNF level was negatively correlated with SDS score. Logistic regression analyses revealed that menstrual status, chronic diseases, serum inflammatory factors (CRP, IL-6 and TNF-α) and BDNF levels had independent predictive values for depression in patients with perimenopausal syndrome (P<0.05). In conclusion, levels of serum CRP, IL-6, TNF-α and BDNF can be used as judgment indicators for the severity of depression.
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May-2018
Volume 15 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Guo L, Ren L and Zhang C: Relationship between depression and inflammatory factors and brain-derived neurotrophic factor in patients with perimenopause syndrome. Exp Ther Med 15: 4436-4440, 2018.
APA
Guo, L., Ren, L., & Zhang, C. (2018). Relationship between depression and inflammatory factors and brain-derived neurotrophic factor in patients with perimenopause syndrome. Experimental and Therapeutic Medicine, 15, 4436-4440. https://doi.org/10.3892/etm.2018.5985
MLA
Guo, L., Ren, L., Zhang, C."Relationship between depression and inflammatory factors and brain-derived neurotrophic factor in patients with perimenopause syndrome". Experimental and Therapeutic Medicine 15.5 (2018): 4436-4440.
Chicago
Guo, L., Ren, L., Zhang, C."Relationship between depression and inflammatory factors and brain-derived neurotrophic factor in patients with perimenopause syndrome". Experimental and Therapeutic Medicine 15, no. 5 (2018): 4436-4440. https://doi.org/10.3892/etm.2018.5985