miR‑202 suppresses prostate cancer growth and metastasis by targeting PIK3CA

Zhang,Shengping; Cai,Jiarong; Xie,Wenjun; Luo,Hui; Yang,Fei

doi:10.3892/etm.2018.6296

miR‑202 suppresses prostate cancer growth and metastasis by targeting PIK3CA

Authors:
- Shengping Zhang
- Jiarong Cai
- Wenjun Xie
- Hui Luo
- Fei Yang
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Affiliations: Department of Urology, The People's Hospital of Longhua, Shenzhen, Guangdong 518109, P.R. China, Department of Urology, The Third Affiliated Hospital of Sun Yat‑Sen University, Guangzhou, Guandong 510630, P.R. China, Department of Operating Room, The Third Affiliated Hospital of Sun Yat‑Sen University, Guangzhou, Guandong 510630, P.R. China
Published online on: June 12, 2018 https://doi.org/10.3892/etm.2018.6296
Pages: 1499-1504

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Abstract

MicroRNA (miR)‑202 has been reported to be involved in the regulation of human cancer progression including bladder cancer, non‑small cell lung cancer, pancreatic cancer and esophageal squamous cell carcinoma. However, the function of miR‑202 in prostate cancer remains largely unknown. The present study demonstrated that miR‑202 was downregulated in human prostate cancer tissues and cell lines. And overexpression of miR‑202 significantly inhibited the proliferation, migration and invasion of prostate cancer cells, but induced cell apoptosis. Moreover, miR‑202 suppressed tumor growth in vivo. Regarding the underlying mechanism, it was revealed that phosphatidylinositol‑4,5‑bisphosphate 3‑kinase catalytic subunit α (PIK3CA) was a target gene of miR‑202 in prostate cancer cells. Overexpression of miR‑202 inhibited the mRNA and protein levels of PIK3CA in prostate cancer cells. Moreover, overexpression of PIK3CA abolished the inhibitory effects of miR‑202 on prostate cancer cell proliferation, migration and invasion in vitro. Taken together, these findings demonstrated that miR‑202 served as a tumor suppressor in prostate cancer by directly targeting PIK3CA.

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