Open Access

Combined diagnosis of breast cancer in the early stage by MRI and detection of gene expression

  • Authors:
    • Dena Ke
    • Rong Yang
    • Lina Jing
  • View Affiliations

  • Published online on: May 31, 2018     https://doi.org/10.3892/etm.2018.6242
  • Pages: 467-472
  • Copyright: © Ke et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Breast cancer is one of the most common cancer types in humans. Magnetic resonance imaging (MRI) is an efficient method for the detection of human breast cancer. However, the efficacy of MRI in detecting breast cancer in the early stage requires to be improved. The present study investigated the diagnostic efficacy of a combination of MRI and detection of gene expression in patients with breast cancer in the early stage. The gene expression levels of Ki‑67, BCL11A, FOXC1, HOXD13, PCDHGB7 and her‑2 were used as an auxiliary diagnostic index for patients with breast cancer in the early stage. Higher expression levels of TPA and C2erbB22 were observed in tumor tissue obtained from diagnostic biopsy and determined by immunohistochemistry, which indicated a higher risk of breast cancer in a total of 84 participants. Diagnostic data revealed that combination MRI and detection of gene expression had a significantly higher diagnostic rate (66/84) in diagnosing breast cancer in an early stage compared with either MRI (78/360) or detection of gene expression (72/84; P<0.01). It was indicated that the combination of MRI and detection of gene expression had a higher diagnostic rate (94.5%) than either MRI (81.4%) or detection of gene expression (75.5%). Histological analysis confirmed the diagnosis determined by MRI and detection of gene expression. These results suggest that the combination of MRI and detection of gene expression may be a potential diagnostic method for assessing patients with early‑stage breast cancer.
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August-2018
Volume 16 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Ke D, Yang R and Jing L: Combined diagnosis of breast cancer in the early stage by MRI and detection of gene expression. Exp Ther Med 16: 467-472, 2018
APA
Ke, D., Yang, R., & Jing, L. (2018). Combined diagnosis of breast cancer in the early stage by MRI and detection of gene expression. Experimental and Therapeutic Medicine, 16, 467-472. https://doi.org/10.3892/etm.2018.6242
MLA
Ke, D., Yang, R., Jing, L."Combined diagnosis of breast cancer in the early stage by MRI and detection of gene expression". Experimental and Therapeutic Medicine 16.2 (2018): 467-472.
Chicago
Ke, D., Yang, R., Jing, L."Combined diagnosis of breast cancer in the early stage by MRI and detection of gene expression". Experimental and Therapeutic Medicine 16, no. 2 (2018): 467-472. https://doi.org/10.3892/etm.2018.6242