Hesperidin protects against IL‑1β‑induced inflammation in human osteoarthritis chondrocytes

Fu,Zhaozong; Chen,Zhongxian; Xie,Qinghua; Lei,Hongjun; Xiang,Shanshan

doi:10.3892/etm.2018.6616

Hesperidin protects against IL‑1β‑induced inflammation in human osteoarthritis chondrocytes

Authors:
- Zhaozong Fu
- Zhongxian Chen
- Qinghua Xie
- Hongjun Lei
- Shanshan Xiang
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Affiliations: Department of Spine Surgery, Jiangmen Central Hospital, Jiangmen, Guangdong 529030, P.R. China
Published online on: August 20, 2018 https://doi.org/10.3892/etm.2018.6616
Pages: 3721-3727

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Abstract

Hesperidin is a vitamin P flavonoid compound primarily present in citrus fruits, which possesses an anti‑inflammatory effect. The functional role of hesperidin in interleukin (IL)‑1β‑stimulated human osteoarthritis (OA) chondrocytes is still unknown. In the present study, anti‑inflammatory effects of hesperidin in IL‑1β‑stimulated chondrocytes were investigated. The results demonstrated that hesperidin treatment markedly decreased nitric oxide and prostaglandin E2 production and markedly downregulated inducible nitric oxide synthase and cyclooxygenase‑2 expression in IL‑1β‑stimulated OA chondrocytes. In addition, hesperidin markedly reduced IL‑1β‑induced matrix metalloproteinase (MMP)‑3 and MMP‑13 expression in human OA chondrocytes. Furthermore, hesperidin markedly decreased the activation of nuclear factor (NF)‑κB in human OA chondrocytes. In conclusion, it was revealed for the first time that hesperidin inhibited inflammatory responses in IL‑1β‑stimulated human chondrocytes, potentially through inhibiting the activation of the NF‑κB signaling pathway. These data suggest that hesperidin may be a potential agent for the treatment of OA.

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