Tanshinone IIA improves diabetes mellitus via the NF‑κB‑induced AMPK signal pathway

  • Authors:
    • Feng‑Yi Yuan
    • Min Zhang
    • Ping Xu
    • Dan Xu
    • Ping Chen
    • Min Ren
    • Qin Sun
    • Jing‑Yan Chen
    • Juan Du
    • Xia‑Lian Tang
  • View Affiliations

  • Published online on: September 3, 2018     https://doi.org/10.3892/etm.2018.6674
  • Pages: 4225-4231
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Abstract

Diabetes mellitus (DM) is a systemic metabolic disease. Tanshinone IIA (Tan‑IIA) presents potential benefits for DM. The purpose of this study was to investigate the efficacy of Tan‑IIA in type 2 DM rats and explore its potential mechanism in renal cells. A type 2 DM rat model was established and administered with Tan‑IIA or PBS. It was demonstrated that Tan‑IIA treatment significantly reduced levels of total cholesterol, non‑esterified fatty acids, total triglyceride and low‑density lipoprotein cholesterol in experimental DM rats compared with the control group. The results indicated that Tan‑IIA treatment significantly decreased levels of interleukin (IL)‑8, tumor necrosis factor‑α, C‑reactive protein and IL‑6. It was identified that Tan‑IIA treatment significantly decreased nuclear factor‑κB levels and significantly elevated 5' adenosine monophosphate‑activated protein kinase levels. Western blot analysis indicated that Tan‑IIA elevated immunocyte precipitation in renal cells. Furthermore, Tan‑IIA treatment improved lipid metabolism, glucose metabolism, insulin resistance and body weight of type 2 DM rats. In conclusion, Tan‑IIA administration may inhibit inflammatory cytokines and alleviate type 2 DM symptoms in experimental rats.
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November-2018
Volume 16 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Yuan FY, Zhang M, Xu P, Xu D, Chen P, Ren M, Sun Q, Chen JY, Du J, Tang XL, Tang XL, et al: Tanshinone IIA improves diabetes mellitus via the NF‑κB‑induced AMPK signal pathway. Exp Ther Med 16: 4225-4231, 2018
APA
Yuan, F., Zhang, M., Xu, P., Xu, D., Chen, P., Ren, M. ... Tang, X. (2018). Tanshinone IIA improves diabetes mellitus via the NF‑κB‑induced AMPK signal pathway. Experimental and Therapeutic Medicine, 16, 4225-4231. https://doi.org/10.3892/etm.2018.6674
MLA
Yuan, F., Zhang, M., Xu, P., Xu, D., Chen, P., Ren, M., Sun, Q., Chen, J., Du, J., Tang, X."Tanshinone IIA improves diabetes mellitus via the NF‑κB‑induced AMPK signal pathway". Experimental and Therapeutic Medicine 16.5 (2018): 4225-4231.
Chicago
Yuan, F., Zhang, M., Xu, P., Xu, D., Chen, P., Ren, M., Sun, Q., Chen, J., Du, J., Tang, X."Tanshinone IIA improves diabetes mellitus via the NF‑κB‑induced AMPK signal pathway". Experimental and Therapeutic Medicine 16, no. 5 (2018): 4225-4231. https://doi.org/10.3892/etm.2018.6674