Open Access

Effects of gastrodin on 5-HT and neurotrophic factor in the treatment of patients with post-stroke depression

  • Authors:
    • Gang Li
    • Yunxia Ma
    • Jinming Ji
    • Xingyan Si
    • Qijiang Fan
  • View Affiliations

  • Published online on: September 19, 2018     https://doi.org/10.3892/etm.2018.6760
  • Pages: 4493-4498
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Abstract

Effects of gastrodin on 5-HT and neurotrophic factor in the treatment of patients with post-stroke depression (PSD) were investigated. A total of 78 PSD patients were selected in Binzhou City Center Hospital from September 2013 to December 2016. Patients were randomly divided into the control group and experimental group, 39 patients in each group. Patients in the control group were treated with conventional drug fluoxertine hydrochloride for 2 months, and patients in the experimental group were treated with gastrodin. The levels of 5-HT and neurotrophic factors in blood were measured using the enzyme-linked immunosorbent assay (ELISA) kit before, and at 1 and 2 months after treatment. The Hamilton Depression Scale (HAMD), Activities of Daily Living (ADL) scale, NIH Stroke Scale/Score (NIHSS) and Stroke Impact Scale (SIS) were used to evaluate the efficacy of treatment. Treatment efficacy was compared between the two groups. The levels of 5-HT and neurotrophic factors were significantly higher in the experimental group than those in the control group at 1 and 2 months after treatment (P<0.05), and HAMD, ADL, NIHSS and SIS scores were all better in the experimental group than in the control group (P<0.05). In addition, significantly less side effects were found in the experimental group than that in the control group, and treatment efficacy in the experimental group was significantly better than that in the control group (P<0.05). Gastrodin is effective in the treatment of PSD and should be popularized.
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December-2018
Volume 16 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Li G, Ma Y, Ji J, Si X and Fan Q: Effects of gastrodin on 5-HT and neurotrophic factor in the treatment of patients with post-stroke depression. Exp Ther Med 16: 4493-4498, 2018
APA
Li, G., Ma, Y., Ji, J., Si, X., & Fan, Q. (2018). Effects of gastrodin on 5-HT and neurotrophic factor in the treatment of patients with post-stroke depression. Experimental and Therapeutic Medicine, 16, 4493-4498. https://doi.org/10.3892/etm.2018.6760
MLA
Li, G., Ma, Y., Ji, J., Si, X., Fan, Q."Effects of gastrodin on 5-HT and neurotrophic factor in the treatment of patients with post-stroke depression". Experimental and Therapeutic Medicine 16.6 (2018): 4493-4498.
Chicago
Li, G., Ma, Y., Ji, J., Si, X., Fan, Q."Effects of gastrodin on 5-HT and neurotrophic factor in the treatment of patients with post-stroke depression". Experimental and Therapeutic Medicine 16, no. 6 (2018): 4493-4498. https://doi.org/10.3892/etm.2018.6760