Oridonin enhances the radiosensitivity of lung cancer cells by upregulating Bax and downregulating Bcl‑2

  • Authors:
    • Sirui Li
    • Dan Shi
    • Liangyu Zhang
    • Fang Yang
    • Guanghui Cheng
  • View Affiliations

  • Published online on: September 27, 2018     https://doi.org/10.3892/etm.2018.6803
  • Pages: 4859-4864
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Oridonin is an active component of the traditional Chinese herb Rabdosia rubescens. The present study aimed to evaluate the antitumor effects of oridonin on human non‑small cell lung cancer (NSCLC) cells and explore whether oridonin could enhance their radiosensitivity. Oridonin was demonstrated to inhibit the proliferation of SPC‑A‑1 and HCC827 lung cancer cells in a time‑ and dose‑dependent manner, which was detected using the MTT assay. In addition, pretreatment with oridonin for 24 h prior to irradiation was identified to enhance the radiosensitivity of SPC‑A‑1 cells. Furthermore, the levels of apoptosis regulator BAX (Bax) and apoptosis regulator Bcl‑2 (Bcl‑2) were detected by western blotting analysis. The results demonstrated that the level of Bax was increased and the level of Bcl‑2 was decreased in SPC‑A‑1 cells treated with oridonin and irradiation compared with the group that received irradiation alone. These results indicate that oridonin may have a novel application as a radiosensitizing agent for the treatment of human NSCLC.
View Figures
View References

Related Articles

Journal Cover

December-2018
Volume 16 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Li S, Shi D, Zhang L, Yang F and Cheng G: Oridonin enhances the radiosensitivity of lung cancer cells by upregulating Bax and downregulating Bcl‑2. Exp Ther Med 16: 4859-4864, 2018
APA
Li, S., Shi, D., Zhang, L., Yang, F., & Cheng, G. (2018). Oridonin enhances the radiosensitivity of lung cancer cells by upregulating Bax and downregulating Bcl‑2. Experimental and Therapeutic Medicine, 16, 4859-4864. https://doi.org/10.3892/etm.2018.6803
MLA
Li, S., Shi, D., Zhang, L., Yang, F., Cheng, G."Oridonin enhances the radiosensitivity of lung cancer cells by upregulating Bax and downregulating Bcl‑2". Experimental and Therapeutic Medicine 16.6 (2018): 4859-4864.
Chicago
Li, S., Shi, D., Zhang, L., Yang, F., Cheng, G."Oridonin enhances the radiosensitivity of lung cancer cells by upregulating Bax and downregulating Bcl‑2". Experimental and Therapeutic Medicine 16, no. 6 (2018): 4859-4864. https://doi.org/10.3892/etm.2018.6803